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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In cases of missed abortion and missed labor, labor was induced by PGF2 alpha i.a., i.v. and by oxytocin infusion. Platelet function (methods of Born and Breddin), the coagulation system and fibrinolysis have been studied within the three groups. Using PGF 2 alpha i.v., the initially increased platelet aggregation showed a tendency to become normal. There was no manifestation of activation of the coagulation system. Fibrinolytic activity showed a slight increase during PGF2 alpha i.v. No essential changes in platelet function, coagulation and fibrinolytic system were found after i.a. injection of PGF2 alpha. When inducing labor by oxytocin i.v., both the coagulation and the fibrinolytic system were slightly activated and platelet aggregation increased. The results and their clinical importance for hemostasis as well as therapeutic consequences are discussed.
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PMID:Platelet function, coagulation and fibrinolysis during termination of missed abortion and missed labor by PGF2 alpha and oxytocin. 52 69

Labor was successfully induced in 20 patients with a diagnosis of missed abortion or intrauterine fetal death (IUFD) by intravaginal administration of prostaglandin E2 suppositories. Fifteen patients delivered with the prostaglandin alone while a concomitant oxytocin infusion was employed to augment contractions in the other five patients. The mean induction-delivery time was 9.80 hours; nulliparous patients delivered in a mean time if 7.78 hours, parous patients in a mean time of 12.29 hours. The uterus appeared to be sensitive to the PGE2 stimulation in all patients and all were delivered completely without the need for surgical intervention. Fifty per cent of patients were delivered within 8 hours and 80 per cent by 12 hours. The side effects associated with prostaglandin administration--vomiting, diarrhea, and temperature elevation--were well tolerated and therapy did not have to be terminated in any patient. The administration of PGE2 vaginal suppositories offers an effective and safe technique for the induction of labor in patients with IUFD. Labor can be induced with PGE2 suppositories as soon as the diagnosis of IUFD is confirmed, which eliminates the need for waiting until spontaneous labor occurs.
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PMID:Induction of labor in patients with missed abortion and fetal death in utero with protaglandin E2 suppositories. 55 89

Platelet function has been studied during intravenous, intraamniotic, and extraamniotic administration of prostaglandin F2alpha (PgF2alpha) for termination of missed abortion and missed labor, for therapeutic abortion, and for induction of term labor. The controls received oxytocin i.v. (missed labor and term labor). Our investigations have shown that there was a normalization of the increased spontaneous platelet aggregation and a significant reduction of ADP- and collagen-induced platelet aggregation in the groups given PgF2alpha i.v. The desaggregation in these groups was increased. The other groups given PgF2alpha showed no significant changes in platelet function. Inducing labor by oxytocin we found a tendency to increased platelet aggregation and decreased desaggregation. The clinical importance of these findings and the consequences for hemostasis are discussed.
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PMID:Studies on platelet function during different modes of administration of PgF2alpha in obstetrics and gynecology. 58 Oct 52

Prostaglandin (PG) gels were used to induce second-trimester abortion in 141 women aged 16-44 years, 1973-1976. PGE2 gel was used alone for 65 women, and in combination with oxytocin for 25 women; PGF2-alpha was used alone for 15, and combined with oxytocin for 36. Indications were: medical (5 cases), psychosocial (97 cases), and missed abortion or fetal death in utero (39 cases). The gel was administered extra-amniotically via catheter; abortion occurred within 36 hours in 136 cases. Mean administration abortion interval varied from 9 hours 52 minutes to 16 hours 17 minutes. A dose-response relationship was noted between the prostaglandin dose and the interval to abortion. Side effects included vomiting (29 cases), diarrhea (2 cases), fever (9 cases), hemorrhage (14 cases), endometritis (2 cases), and circulatory symptoms (2 cases) and torn cervix (1 case). No signficant differences between primigravidae and others were observed.
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PMID:[Therapeutic abortions in the second trimestre of pregnancy with prostaglandine gel (author's transl)]. 64 Mar 66

In a group of 16 women admitted for missed abortion, missed labor or antepartum fetal death, we induced abortion or labor by means of extraamniotic infusion of isotonic saline solution, using a Foley catheter inserted through the cervix. Eight patients also required parallel intravenous administration of 5-10 U of oxytocin drip. The average time from the onset of treatment until expulsion of the macerated fetus was 9.09 hours. No complications were recorded. This method is suggested in all such cases, especially when the classical methods are contraindicated.
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PMID:Induction of abortion and labor by extraamniotic isotonic saline, with or without addition of oxytocin, in cases of missed abortion, missed labor and antepartum fetal death. 84 75

Extraamniotic PGE2 and iv oxytocin in termination of midtrimester pregnancy and in the management of missed abortion and hydatiform mole are reported. 18 patients were divided into 2 groups: 1) 12 patients received an initial dose of 200 mcg of PGE2 and subsequent instillations of 100-200 mcg/hour. If abortion was not achieved in 12 hours, oxytocin was started. 2) 6 patients received an initial dose of 500 mcg of PGE2 and subsequent instillations with 500 mcg at 4, 6, and 8 hours, respectively. If abortion was not achieved by 6 hours, oxytocin was started. Abortion was achieved in all patients; 15 within 24 hours. Comcomitant administration of extraamniotic PGE2 and iv oxytocin was shown to be a safe and efficient way of inducing midtrimester abortion, missed abortion, and hydatiform mole. This methods is associated with minimum side effects and complications.
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PMID:Extra-amniotic prostaglandin E2 and intravenous oxytocin in termination of mid-trimester pregnancy and the management of missed abortion and hydatiform mole. 90 15

Termination of pregnancy in missed abortion and intra-uterine fetal death was accomplished using vaginal suppositories of 20 mg PGE2 in 31 cases and the results were compared with oxytocin induction (with or without estrogen pre-treatment) in 17 cases at the doses routinely used in our hospital. The PG suppositories proved much more superior (96.7%) than oxytocin (47.7%), but induced a higher rate of side effects. The latter were not serious and were generally tolerated by the patients. There was a positive correlation between duration of fetal retention in utero and the induction expulsion time. The over all patient acceptance of the method was quite favourable and the approach appears to be a definite advance towards management of these cases.
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PMID:Management of missed abortion and fetal death in utero. 90 80

76 therapeutic abortions and 16 labors for missed abortion were induced by extraamniotic isotonic saline with or without oxytocin. Saline was perfused with a Number 16 or 18 Foley catheter, just inside the cervical os, at 16 drops/minute. After 2 hours oxytocin was infused iv if needed. A 2nd saline perfusion was given in some cases. Uterine contractions started in 15-30 minutes; mean time to abortion ranged from 5 to 50 hours; mean time to delivery of the macerated fetus was 7 hours, 45 minutes. This method was remarkably safe, with no complications, even in patients with hemolytic anemia, Caesarean section scars, fibroids, and a 10-week pregnancy. it would be appropriate when hypertonic saline or prostaglandins are contraindicated, such as in renal, cardiac, or respiratory disease, when coagulation disorders are likely, when the amniotic sac is difficult to puncture, and when a fetus in good condition is needed for genetic or embryologic studies.
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PMID:[Indications of choice for extra-amniotic perfusion of physiologic serum]. 95 36

To evaluate intracervical PGE2 plus low dose oxytocin in the induction of cervical changes and labor, we studied 36 pregnant patients who had one of the following complications: Intrauterine death, anencephaly, gestational trophoblastic disease, missed abortion and PRM with pregnancy less than 28 weeks of gestational age. 200 mcgs of PGE2 were applied in the cervix, and immediately an oxytocin infusion was started at 2 mlU, the dose of oxytocin was increased in the arithmetic fashion until labor was started. The latency between the application of PGE2 and the beginning of labor was 3.57 +/- 3.29 h., between the beginning of labor and birth was 5.59 +/- 3.39 h. The cervix changed from a Bishop score of 2.1 +/- 1.5 to 6.2 +/- 1.8 (p less than 0.0001). The hospital stay was of 1.6 +/- 0.6 days. The secondary affects were minimal, and the births were all vaginal.
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PMID:[Inductoconduction with unfavorable cervix. PGE2 plus oxytocin for the induction of labor in complicated pregnancies]. 206 4

Prostaglandin F2a was used for termination of pregnancy in two groups of patients. The first included eighteen patients with either missed abortion or intrauterine fetal death, and were treated by intrauterine-extraamniotic infusion of 20 mg prostaglandin F2a. The treatment was successful in 14 patients (mean induction-abortion interval 6.7 hours). Four patients, where the above method failed to induce labor, were given intravenously prostaglandin F2a or oxytocin simultaneously or separately; the expulsion time ranged from 12 to 48 hours. The second group included twelve patients who underwent a therapeutic abortion following either a diagnosis of fetal congenital abnormality or because of a maternal indication. The therapeutic abortion was performed using prostaglandin F2a (25-40 mg) via amniocentesis. The treatment was successful in all patients (mean induction-delivery interval 10.6 hours).
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PMID:Intra/extra-amniotic administration of prostaglandin F2a in fetal death, missed and therapeutic abortions. 219 5


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