Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01034 (cystatin C)
 3,397 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cystatin C, a protein inhibitor of lysosomal cysteine proteinases, was demonstrated by immunohistochemical techniques to be present in most luteinizing hormone- (LH-)containing cells in simian and human adenohypophyses. Immunoreactivity of cystatin C was also found in simian adrenocorticotrophic hormone- (ACTH-)containing cells localized to an area corresponding to the pars intermedia but not in the ACTH-containing cells of the anterior pituitary lobe of monkey. No immunoreactivity of cystatin C was detected in the growth hormone- (GH-) and prolactin-containing cells of monkey and man.
 ...
PMID:Distribution of cystatin C (gamma-trace), an inhibitor of lysosomal cysteine proteinases, in the anterior lobe of simian and human pituitary glands. 299 51

gamma-Trace, a small protein occurring in body fluids and in secretory and neuroendocrine cells, was demonstrated by immunohistochemical techniques in the cytoplasm of the tumor cells of 13 pituitary adenomas obtained at surgery and autopsy. Seven of the adenomas also contained LH immunoreactivity. FSH, TSH, and ACTH were each found in one gamma-trace-containing adenoma. gamma-Trace was also demonstrated in extracts of 1 pituitary adenoma and of 5 nontumorous adenohypophyses. The immunoreactive protein found in the extracts had a molecular weight and electrophoretic mobility characteristic of gamma-trace. Computerized amino acid sequence comparisons between the primary structure of gamma-trace and those of known hormonal peptides showed no significant similarities.
 ...
PMID:gamma-trace in human pituitary adenomas. 637 15

The localization of cathepsin B, a potential promoter of prolactin (PRL) release via extra renal renin-angiotensin system in the adenohypophysis, and its inhibitor cystatin C in the human adenohypophysis and in pituitary adenomas were examined using single and dual immunohistochemical staining. In the adenohypophysis, cathepsin B was expressed in about 50% of the ACTH-producing cells, and in 5% or less of the GH- and PRL-producing cells. In contrast, cystatin C was expressed in about 70% of the GH- and PRL-producing cells, but in only 5% or less of the ACTH-producing cells. PRL-producing adenomas strongly expressed cathepsin B, but only weakly expressed cystatin C, a pattern of staining contrary to the expression in normal PRL-producing cells. The above results suggest that cathepsin B may play a role in promoting PRL release especially in PRL-producing adenomas.
 ...
PMID:Expression of cathepsin B and cystatin C in the human adenohypophysis and in pituitary adenomas. 1060 86