Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01034 (
cystatin C
)
3,397
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Thyroid hormones increase
cystatin C
levels in vivo. To study whether 3,3',5-triiodo-l-thyronine (T(3)) stimulates the production of
cystatin C
in vitro, we used a T(3)-responsive osteoblastic cell line (PyMS) which can be kept in serum-free culture. We compared the effects of T(3) on
cystatin C
mRNA expression (by Northern) and on protein release (by Western and ELISA) with those of dexamethasone (dex).
Triiodothyronine
increased
cystatin C
mRNA expression and
cystatin C
accumulation in culture media in a dose- and time-dependent manner, 1.5-fold at 1 nmol/l after 4d; dex (100 nmol/l) was more potent and increased
cystatin C
accumulation 3-fold after 4d.
Triiodothyronine
but not dex stimulated glucose uptake. Our in vitro findings explain in vivo observations.
Triiodothyronine
-induced increase in the production of
cystatin C
may be related to an increased cell metabolism and proteolysis control demand.
...
PMID:Triiodothyronine stimulates cystatin C production in bone cells. 2236 Aug 52
