Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01034 (
cystatin C
)
3,397
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of asthma pathogenesis on serum
cystatin C
, a potent inhibitor of cysteine proteinases and a newly proposed marker of the renal function, has not been yet determined. The objectives were to determine the 24-h pattern of
cystatin C
and creatinine concentrations in sera of asthmatic patients in order to test whether their concentrations might reflect circadian rhythms, the disease severity and the effect of therapy. Serum concentrations of
cystatin C
and creatinine were determined in steroid-independent and steroid-dependent asthmatics before and after 1 week of treatment with methylprednisolone and cyclosporin A, respectively. Samples were collected every 4 h during a 24-h period. Little or no significant effects of time on
cystatin C
and creatinine concentrations over a 24-h period were observed in healthy and asthmatic sera. However, significantly higher
cystatin C
concentrations were found in asthmatic patients compared to controls which suggests its role in the pathogenesis of asthma.
Methylprednisolone
increased and cyclosporin A decreased serum
cystatin C
concentrations after 1 week of therapy. Additionally these results support the need for the evaluation of
cystatin C
as a marker of glomerular filtration rate determination in asthma.
...
PMID:Serum cystatin C, a potent inhibitor of cysteine proteinases, is elevated in asthmatic patients. 1095 65
