Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01034 (cystatin C)
 3,397 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the study was to assess whether NGAL and cystatin C could predict contrast-induced nephropathy in non-diabetic patients (n=60, mean age 60+/-11 years) with normal serum creatinine undergoing elective PCI. We found a significant rise in serum NGAL after 2, 4 and 8 h, and in urinary NGAL after 4, 8 and 24 h after PCI. Cystatin C rose significantly 8 and 24 h after the procedure. Prevalence of CIN was 10%. We found 90% sensitivity and 74% specificity of serum and 76% sensitivity and 80% specificity of urinary NGAL increase. NGAL may represent a sensitive early biomarkers of renal impairment after PCI.
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PMID:NGAL (neutrophil gelatinase-associated lipocalin) and cystatin C: are they good predictors of contrast nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine? 1756 73

Critically ill patients are at high risk for developing acute renal failure (ARF). The prevention of ARF is of outmost importance in order to improve the increased morbidity and mortality associated with ARF. Unfortunately, there is lack of adequate endogenous markers that can identify renal dysfunction early - this hampers timely application of measures to prevent further renal damage. The use of exogenous markers of renal function is not only time-consuming but also expensive, and therefore can not be used on a regular basis in the intensive care unit. Both the presently used endogenous and exogenous markers are not reliable during continuous renal replacement therapy (CRRT) because these markers are removed by the therapy itself impeding early detection of recovering of renal function. Cystatin C has been proposed as an alternative endogenous marker of renal function for more than 15 years. In this manuscript we review the literature on the role of cystatin C as marker for renal function, focusing on the critically ill patient. Serum cystatin C concentrations have been found to relate to renal impairment and suggest that cystatin C is more sensitive to detect mild decreases in GFR. Cystatin C could be an important tool both to recognize early renal dysfunction and to identify renal recovery while on CRRT in the critically ill patient, however, we are in need of more studies.
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PMID:Serum cystatin C-A useful endogenous marker of renal function in intensive care unit patients at risk for or with acute renal failure? 1789 79

The value of neutrophil-gelatinase-associated lipocalin (NGAL) was highlighted as a novel biomarker for the detection of acute renal failure. We tested the hypothesis whether NGAL could represent an early biomarker of contrast-induced nephropathy (CIN) in 100 patients with normal serum creatinine values undergoing percutaneous coronary interventions (PCI). In addition, we assessed serum and urinary NGAL in relation to cystatin C, estimated glomerular filtration rate, and serum and urinary creatinine in these patients. We measured urinary and serum NGAL values before and 2, 4, 8, 24, and 48 h after the PCI. We found a significant rise in serum NGAL levels 2, 4, and 8 h after the PCI and in urinary NGAL values 4, 8, and 24 h after a PCI procedure. Cystatin C rose significantly 24 h after the procedure. The prevalence of CIN was 11%. The NGAL levels were significantly higher 2 h after the PCI (serum NGAL) or 4 h after the PCI (urinary NGAL), whereas the cystatin C values were higher only 8 and 24 h after a PCI procedure in patients with CIN. In multivariate analysis, only serum creatinine was a predictor of serum NGAL before a PCI. NGAL may represent a sensitive early biomarker of renal impairment after PCI. Serum creatinine level, the presence of diabetes, and the duration of the PCI may affect serum NGAL values and kidney function following a PCI procedure.
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PMID:Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values? 1790 10

Because of incompatible reports about the renal impairment to abdominal aortic aneurysm (AAA) repair, we conducted a prospective study to determine the differences in renal response between open (OR) and endovascular (EVAR) aneurysm repair. In a prospective, nonrandomized, single-center study, we evaluated 485 patients with AAAs undergoing OR or EVAR between January 2000 and December 2005. Only electively performed procedures were analyzed in detail. The OR group included 229 patients (males/females 203/26, median age 69.8 [range 43-90] years, aneurysm diameter in median 57 [26-95] mm), and the EVAR group integrated 144 patients (males/females 129/15, 73.1 [49-90] years [p=.001], 55 [33-100] mm). Renal function was assessed by determinating the preoperative serum creatinine (SCr) level and SCr clearance according to Cockcroft-Gault. Postoperatively, SCr level and SCr clearance were determined at defined intervals, reported as highest postoperative SCr level, SCr level at time of discharge, lowest postoperative SCr clearance, and SCr clearance at time of discharge. The parameters of height, weight, diabetes, smoking habit, serum cholesterol level, and hemoglobin were not different between the groups. Significantly different were the American Society of Anesthesiologists classification, the Society for Vascular Surgery Comorbidity Score, and the exposure to contrast dye. Moreover, significantly different were intraoperatively measured median blood loss (1,200 vs. 400 mL) and the median time of operation (164 vs. 135 min). Although, the preoperative SCr levels between the groups were not statistically different (OR group 1.0 [0.87-1.23] mg/dL [median, interquartile range], EVAR group 1.0 [0.9-1.3]; p > 0.05), the SCr clearance was (OR group 72.8 [58.2-98.8] mL/min, EVAR group 67.6 [51.3-85.1] mL/min; p = 0.007). In the postoperative period, SCr level did not change significantly in the OR group but did in the EVAR group to a level of 1.08 (0.9-1.36) mg/dL (p = 0.007). Similarly, SCr clearance decreased significantly in the EVAR group to a level of 66.7 (49.9-81.4) mL/min. These results were influenced by the stent graft design (deployment under the renal arteries vs. covering the renals with bared stents). Mortality was 3/229 in the OR group and 4/144 in the EVAR group. Acute renal impairment occurred in a subset of patients with AAAs with regard to the type of repair. EVAR showed a slight deterioration of renal function, but the evaluated tests are insensitive and without prognostic value concerning mortality or hospitalization. More sensitive markers of the differentiated renal functions (cystatin C for renal glomerular function, N-acetyl-ss-d-glucosamidase for proximal tubular function) should be evaluated in future studies.
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PMID:Renal response to open and endovascular repair of abdominal aortic aneurysm: a prospective study. 1805 73

Cystatin C is a 13-kDa protein, of the cysteine proteinase inhibitor superfamily, produced by all nucleated cells. Its production rate is constant throughout the ages of 1 to 50 years. It is freely filtered at the glomerulus and then resorbed and fully catabolised by proximal renal tubules, making it an ideal marker of glomerular filtration rate (GFR). Serum creatinine, the most established marker of renal function, is affected by age, gender, muscle mass, nutritional status and analytical interference. The abbreviated Modification of Diet in Renal Diseases (MDRD) equation has recently been introduced in an attempt to overcome these shortcomings, but still has many limitations. Cystatin C is not affected by gender, muscle mass, malignancy, its production rate is usually constant and its plasma concentration therefore is dependent only on GFR. Cystatin C has been demonstrated to be more accurate than serum creatinine in the detection of early renal impairment and in specific populations may allow for early detection of renal disease. Cystatin C has also been found to be a strong predictor of long-term clinical outcomes in patients with cardiovascular diseases. Although cystatin C may have advantages in detection of early renal impairment there is a paucity of evidence that it significantly improves clinical decision making over creatinine. This coupled with assay cost may be the reason why cystatin C, although well recognised, has not been introduced into routine operational use, although that may eventuate with emerging evidence.
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PMID:Cystatin C--a paradigm of evidence based laboratory medicine. 1878 43

The onset of diabetic nephropathy is characterised by a rise in albumin excretion rate (AER) and/or a transient rise in glomerular filtration rate (GFR) (hyperfiltration). Without intervention AER increases exponentially and there is a linear decrease in GFR after onset of overt nephropathy. In overt nephropathy, AER is a predictor of decline in GFR and the early AER response to antihypertensive therapy correlates with long-term decline in GFR. AER can be measured by immunoassay or by other techniques including HPLC. However, HPLC assays result in higher levels of AER in normal subjects compared with immunoassayable AER. Recent data suggest that there are distinct albuminuric and non-albuminuric pathways to renal impairment in type 1 and type 2 diabetes. In type 2 diabetes, the non-albuminuric pathway may explain a decline in GFR to <60 ml/min/1.73 m(2) in approximately one in four subjects after accounting for the use of renin angiotensin system inhibitors. In established nephropathy (chronic kidney disease (CKD) stages 3 and 4), plasma cystatin C based estimates of GFR are marginally superior to creatinine based estimates. However, cystatin C clearly outperforms creatinine based estimates of GFR decline at GFR levels >60 ml/min/1.73 m(2) (CKD stages 1 and 2). Other potential markers of progression of diabetic nephropathy include transforming growth factor beta (TGFbeta) and connective tissue growth factor (CTGF). However, long-term studies are needed to define their roles as markers of progression. Diabetic nephropathy is likely to be more susceptible to intervention at an early stage and accurate estimation of GFR is already possible with cystatin C. However, improved formulas for estimating GFR based on using creatinine or other markers are still required, because this may still provide the most cost effective approach applicable to existing clinical practice.
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PMID:New and old markers of progression of diabetic nephropathy. 1893 92

Renal impairment is common during and after severe exercise. In clinical practice, renal function is evaluated using serum creatinine, urine parameters, and equations to estimate the Glomular Filtration Rate (GFR). However, creatinine levels may be biased by skeletal muscle damage and the GFR equations, requiring age, gender and body weight, are shown to be inadequate in normals. In the present study, we show that serum cystatin C and creatinine concentrations were elevated after marathon running in 26% and 46% of the 70 recreational male runners, respectively, possibly because of reduction in renal blood flow. The mean cystatin C increase was twice as low as compared to creatinine (21% and 41%, respectively), suggesting that cystatin C is indeed less biased by muscle damage. Future research has to reveal whether training diminishes the elevation in renal markers. Overall, cystatin C seems a more reliable method to establish renal function during and after extensive exercise.
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PMID:Cystatin C a marker for renal function after exercise. 1954 28

Serum creatinine level is the most commonly used indices for assessment of glomerular filtration rate (GFR), even though these indices have been shown to have some limitations in clinical practice. We investigated the diagnostic efficacy of serum cystatin C compared to that of serum creatinine levels and identified the relating factors associated with changes in serum cystatin C levels in gout patients with renal impairment. A total of 68 gouty patients with renal impairment were enrolled in this study. Diagnostic efficacy of serum cystatin C levels was evaluated through non-parametric receiver operating characteristic (ROC) analysis. The risk factors for changes in serum cystatin C levels were confirmed using multivariate regression analysis. With 24-hr urine creatinine clearance (Ccr) as the reference for GFR, 1/cystatin C (r=0.702, P<0.001) showed a significantly higher correlation with Ccr than 1/creatinine (r=0.665, P<0.001). Multivariate correlation analysis demonstrated that the clinical parameters for increased serum cystatin C are a higher stage of chronic kidney disease, older age, use of allopurinol, and lower high density lipoprotein-cholesterol. The area under the curve (AUC) at ROC plots identified that of serum cystatin C was significantly greater than that of serum creatinine (AUC 0.804 of cystatin C and AUC 0.745 of creatinine). The study suggests that serum cystatin C is a reliable endogenous marker for the assessment of renal function or GFR in gout patients with renal impairment.
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PMID:Serum cystatin C is a potential endogenous marker for the estimation of renal function in male gout patients with renal impairment. 2005 46

The progressive decline of renal function with aging is not inevitable, because it is mainly due to comorbid conditions such as hypertension and diabetes. However, in the elderly there is a high prevalence of chronic kidney disease leading to the need for strategies to control cardiovascular risk - death being far more common than dialysis at all stages of kidney function. Serum creatinine, the most widely used surrogate marker of glomerular filtration rate (GFR), is inaccurate with increasing age, particularly in sick and/or malnourished elderly people; it shows the so-called creatinine blind area, and substantial variation between laboratory analytical methods. An alternative endogenous marker is serum cystatin C: it correlates better with renal function and has the potential advantage of improved precision of the assay, but its measurement is still much more expensive. Current guidelines recommend that the 2 most commonly used equations to estimate GFR - the Modification of Diet in Renal Disease Study or Cockcroft-Gault equations - be used to estimate GFR in the clinical setting. Both show relevant bias, with underestimation of GFR in subjects with normal or mild renal impairment, a bias limited by using the more recent Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Nonetheless, keeping in mind that a decreased renal function in the elderly is not benign, current GFR equations facilitate detection, evaluation and management of the disease, and they should result in improved patient care and better clinical outcomes.
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PMID:How to assess renal function in the geriatric population. 2087 71

We performed a cross-sectional study to determine the best method for estimating the glomerular filtration rate (GFR) in HIV-infected subjects. Isotopic GFR was correlated with 24-h urine creatinine clearance, cystatin C levels, and 3 creatinine-based equations-the Modification of Diet in Renal Disease (MDRD), Cockcroft-Gault (CG), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)-in 15 patients. Cystatin C showed the strongest correlation with isotopic GFR (r=-0.760, p=0.001). When cystatin C was used as the reference variable for all 106 patients, CKD-EPI proved to be superior to the other equations (r=-0.671, p<0.001). Time with HIV infection, unsuppressed viral load, low CD4 T-cell counts, and use of protease inhibitors are related to an increased risk of renal impairment, leading us to recommend early initiation of antiretroviral therapy accompanied by a regular renal study.
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PMID:Validation of estimated renal function measurements compared with the isotopic glomerular filtration rate in an HIV-infected cohort. 2088 53


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