Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01034 (cystatin C)
 3,397 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Management of renal transplant patients requires periodic measurement of renal function, which is usually assessed by measuring the glomerular filtration rate (GFR). The most commonly used marker for GFR is serum creatinine, although muscle wasting and tubular secretion may lead to overestimation of the actual GFR. Serum concentrations of the low-molecular-weight proteins, cystatin C and beta(2)-microglobulin (B(2)M), may afford useful markers to determine a reduced GFR. We investigated whether these molecules provide reliable indicators of renal function in 75 renal transplant patients. Cystatin C and B(2)M correlated significantly with creatinine (r =.648, P <.05 and r =.578, P <.05, respectively). Inverse serum creatinine was superior to inverse cystatin C and inverse B(2)M when renal function equations were used (r =.95, P <.05, according to MDRD; r =.87, P <.05, according to Cockroft-Gault). Receiver operating characteristic (ROC) analysis was performed to quantitate the accuracy of the different markers to detect reduced GFR using a cutoff value of 70 mL/min. No significant difference between the areas under the ROC curves comparing cystatin C and B(2)M was observed; however, serum creatinine demonstrated a significantly greater value than cystatin C (.981 vs.724, P =.001). We conclude that serum creatinine is a more efficacious marker than serum cystatin C to assess renal function.
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PMID:Serum cystatin C as an index of renal function in kidney transplant patients. 1501 12

Chronic kidney disease (CKD) Clinical Practice Guide 2012 for Japanese (CKD guide 2012) was released to update CKD guide 2009. Classification of CKD was altered according to the classification of KDIGO 2012 CKD Clinical Practice Guideline, which was based on cause, glomerular filtration rate (GFR) categories, and albuminuria categories. Because evaluation of albuminuria is not common for most CKD subjects in Japan, proteinuria categories comparable to the albuminuria categories were added to CKD Guide 2012. A GFR equation based on serum creatinine is recommended and has been used for evaluation of renal function. In CKD Guide 2012, a GFR equation based on serum cystatin C was also included. Serum cystatin C is a new GFR marker. Recently, measurement of cystatin C was standardized using international certified reference material ERM-DA471/IFCC. A new GFR equation based on standardized serum cystatin C was developed for Japanese. Estimated GFR based on serum creatinine (eGFRcreat) is influenced by not only renal function but also muscle mass. It might be overestimated in subjects with low muscle mass, such as muscle wasting diseases, and underestimated in those with high muscle mass, such as athletes. Estimated GFR based on serum cystatin C (eGFRcys) is little-influenced by muscle mass. If eGFRcreat is less accurate, additional evaluation of eGFRcys is useful. Generally, the average value of eGFRcreat and eGFRcys(eGFRaverage) is most accurate.
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PMID:[Development of evaluation of kidney function and classification of chronic kidney disease (CKD)--including CKD clinical practice guide 2012]. 2420 4