Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P00790 (PGA)
 2,475 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Callus formation in the periosteal bone interface in response to bone morphogenetic protein (BMP) and associated bone matrix noncollagenous proteins (BMP/NCP) was investigated in mature adult rabbits. For controls byproducts of BMP/NCP purification, bone marrow, eight nonskeletal tissues, purified matrix gamma-carboxyglutamic acid-rich protein (MGP), and a composite of BMP/NCP and polylactic-polyglycolic acid polymer (PLA/PGA) were also implanted in the periosteal bone interface. Quantitative microcomputer image analysis and histologic studies were performed three weeks after the implantation. BMP/NCP and bone marrow or BMP/NCP implanted over a single drill hole into the marrow cavity produced three times more new bone than the bone marrow alone. BMP/NCP alone produced twice as much new bone as bone marrow alone. Control implants of bovine serum albumin or purified MGP produced no new bone. Autogeneic minced muscle and ten nonskeletal tissue controls produced little or no bone formation. Even at one-fifth of the dose of BMP/NCP, a composite of PLA/PGA incorporating BMP/NCP showed almost the same amount of new bone as BMP alone. Histologically, the response to BMP/NCP consisted of an external callus of calcifying cartilage and woven bone. The response to subperiosteal implants of BMP/NCP or BMP/NCP with bone marrow or with minced muscle occurred with the same sequence of developmental events as seen either in embryonic skeletogenesis or in fracture callus.
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PMID:Induction of callus formation by implants of bone morphogenetic protein and associated bone matrix noncollagenous proteins. 318 May 78

To elucidate the effects of enamel matrix derivative (EMD: Emdogain) on bone regeneration in rat femurs after drill-hole injury, defects in bone were filled with either EMD or its carrier, PGA, as control. On postoperative days 4 to 28, dissected femurs were examined by means of various morphological approaches. In both experimental groups, formation of trabecular bone, which was immunostained for bone sialoproteins (BSP), had occurred in the medullary cavities at cylindrical bone defects on Day 7 postoperatively. Cuboidal osteoblasts were clearly observed on these newly-formed BSP-positive bone trabeculae. On Days 7 and 14, many multinucleated giant cells, which strongly expressed cathepsin K, had appeared on these bone trabeculae, indicating active bone remodeling. In these bone trabeculae, Ca and P weight % and Ca/P ratio were similar to those of cortical bone, and there was no significant difference between the PGA- and EMD-applied groups. Bone volume fraction of newly-formed bone trabeculae on Day 7 postoperatively was significantly higher in the EMD-applied group than in the PGA-applied controls. Because of active bone remodeling and the marked decrease of bone volume, on Days 14 and 28 postoperatively, however, there was no longer a significant difference in trabecular bone volume fraction between the experimental groups. Our results suggest that EMD possesses an osteo-promotive effect on bone and medullary regeneration during wound healing of injured long bones.
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PMID:Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur. 1174 98

Between the late 1930s and mid-1950s, Dr. E. Cary Middlecoff, a one-time dentist from Memphis, Tennessee, and later, professional golfer, set the golf world on fire. His prestigious 16-year amateur and professional record became legendary. During his career, he won 40 professional tournaments, including the 1955 Masters and two U.S. National Open titles (1949 and 1956). Overall, in 91 tournaments, Middlecoff never placed lower than third. Fellow golf professionals acknowledged him as a talented and formidable competitor. He was a long, straight driver and an accomplished long-iron player who possessed an unorthodox, but accurate, putting style. Although he sometimes commented that he became a "bale of nerves" before competing, he was known to perform admirably while under extreme pressure. Cary concentrated on each hole with "exasperating deliberation," and paid compulsive attention to every detail of his game. In spite of his slow and intense play, he refused to dwell on a poor shot, an unproductive hole or a disappointing round. After leaving the tour circuit in 1963, Middlecoff spent the following 18 years working as a TV golf analyst. In 1986, he was elected as a PGA Hall of Fame member.
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PMID:Cary Middlecoff (1921-1998): dentistry's top golfer. 1181 77

A study investigated streakiness among professional golfers. Hole-to-hole scores within 747 tournaments from a randomly chosen group of 35 players on the 1997 PGA Tour were analyzed. Contingency analyses gave no evidence for streakiness. Players were just as likely to score par or better following an above par hole as to make a par or better following a par or better hole. These results are consistent with those found for individual players in baseball and basketball.
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PMID:Examination of hole-to-hole streakiness on the PGA Tour. 1606 Apr 47

A study investigated the "hot hand" among professional golfers. Hole-to-hole scores within 747 tournaments from a randomly chosen group of 35 players on the 1997 PGA Tour were analyzed. Contingency analyses gave no evidence for the "hot hand". Players were just as likely to score a birdie or better following a par or worse hole as make a birdie or better following a birdie or better hole. These results are consistent with those found for individual players in baseball and basketball.
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PMID:An examination of the "hot hand" in professional golfers. 1649 99

The aim of this study was to test the performance of poly-L-lactic/polyglycolic acid (PLLA/PGA) co-polymer plates and screws in the fixation of mandibular fractures. Following clinical and radiographic examination, internal fixation was achieved with PLLA/PGA co-polymer plates and screws in 31 patients. Elastic maxillomandibular fixation was maintained for 4 weeks and a blenderized diet for 6 weeks. Patients were followed up at 1 week, 6 weeks, and 3, 6 and 12 months post surgery, and evaluated clinically for swelling, pain, mucosal discoloration and occlusal relation. Segment stability, fracture healing and screw-hole ossification were assessed radiographically. Of the 29 patients who completed the trial, 20 had an uncomplicated postoperative period, resulting in complete bone union. Radiographic evidence of screw-hole ossification was noted in several patients, with considerable site-dependent rate variation. Nine patients developed complications ranging from minor dehiscence (4 patients) to frank sepsis requiring plate removal (5 patients), resulting in a 22.5% complication rate. There were no cases of non-union at the end of the fixation period. The reported complication rate following titanium internal fixation of mandibular fractures is 13.7%-43%. PLLA/PGA co-polymer plate and screw fixation of mandibular fractures, although technically more challenging and costly, is a viable alternative to traditional metal devices in selected patients.
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PMID:A prospective trial of poly-L-lactic/polyglycolic acid co-polymer plates and screws for internal fixation of mandibular fractures. 1829 49

This study investigated whether the unreliability of golf scores for professional golfers can be accounted for by restriction of range. Reliability estimates for hole-to-hole scores were calculated from data from 2679 players on the PGA Tour, 32 senior club professionals, and 62 men and 49 women amateurs who had won either their club or course championship. Reliability estimates were small and negative for the PGA Tour (Cronbach alphas ranging from -.31 to -.15) but mostly positive and substantially higher for senior club professionals and amateurs (Cronbach alphas ranging from -.46 to .76). It was concluded that the greater reliability of performance for senior club pros and amateurs than for PGA Tour players was due to the greater variability in skills and performance of the club professionals and amateurs.
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PMID:On the unreliability of golf scores for professional golfers: a case for restriction of range. 1923