Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P00790 (
PGA
)
2,475
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The Patlak graphical analysis (
PGA
REF
) for quantification of irreversible tracer binding with a reference tissue model was approximated by a dual time point imaging approach (DTP
REF
). The DTP
REF
was applied to 18 [
18
F]-FDOPA brain scans using the occipital cortex as reference region (DTP
OCC
) and compared to both
PGA
OCC
and striatal-to-occipital ratios (SOR). Pearson correlation analysis and Bland-Altman plots showed an excellent correlation and good agreement between DTP
OCC
and
PGA
OCC
, while correlations between SOR and
PGA
OCC
were consistently lower. Linear discriminant analysis (LDA) demonstrated a similar performance for all methods in differentiating patients with Parkinson's disease (PD) from healthy controls (HC). Specifically for [
18
F]-FDOPA brain imaging, these findings validate DTP
OCC
as an approximation for
PGA
OCC
, providing the same quantitative information while reducing the acquisition time to two short static scans. For PD patients, this approach can greatly improve patient comfort while reducing motion artifacts and increasing image quality. In general, DTP
REF
can improve the clinical applicability of tracers with irreversible binding characteristics when a reference tissue is available.
J
Cereb
Blood Flow Metab 2017 09
PMID:Dual time point method for the quantification of irreversible tracer kinetics: A reference tissue approach applied to [
18
F]-FDOPA brain PET. 2815 11
