Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P00790 (
PGA
)
2,475
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Adsorption of
phenanthrene
on carbon nanotubes (CNTs) and bioaccessibility of adsorbed
phenanthrene
were studied in simulated gastrointestinal fluids. Adsorption of
phenanthrene
on CNTs was suppressed in pepsin (800 mg/L) solution (gastric) and bile salt (500 and 5000 mg/L) fluids (intestinal). In addition to competitive sorption, pepsin and high-concentration bile salt (5000 mg/L, above critical micelle concentration) solubilized
phenanthrene
(3 and 30 times of the water solubility, respectively), thus substantially reduced
phenanthrene
adsorption on CNTs.
Pepsin
and bile salts also increased the rapidly desorbing
phenanthrene
fraction from CNTs. The rapidly desorbing phase lasted less than 1 h for all CNTs. Further, 43-69% of
phenanthrene
was released from CNTs after desorption in the simulated gastric and intestinal fluid at low bile salt concentration while 53-86% was released in the gastric and intestinal fluid at high bile salt concentration. These findings suggest that the release of residual hydrophobic organic compounds from CNTs could be enhanced by biomolecules such as pepsin and bile salts in the digestive tract, thus increasing the bioaccessibility of adsorbed
phenanthrene
and possibly the overall toxicity of
phenanthrene
associated CNTs.
...
PMID:Adsorption and desorption of phenanthrene on carbon nanotubes in simulated gastrointestinal fluids. 2166 86
