Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P00790 (PGA)
 2,475 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Research has shown that several PGs (prostaglandins) influence the following 3 major functions of the gastrointestinal tract: 1) gastric secretion; 2) motor activity; and 3) intestinal ion transport. The clinical and animal research literature on PG effects on motility and intestinal transport is summarized. PGEs and, to a lesser extent, PGF2a influence gastrointestinal motility. PGE, PGA, and PGF2a are involved in the process of water and electrolyte transport by the intestine. The article concentrates on what is known regarding PG effects on gastric secretion. The effect--inhibition of the gastric secretions--occurs in several species and in man. The inhibition includes all components of gastric juice--volume, acid, pepsin, and mucus. The effect is manifest in the basal state and in all secretogogues tested so far. The following mechanisms of action of this effect are discussed: 1) inhibition through changed gastric blood flow; 2) inhibition through a nervous mechanism; 3) operation through the cyclic AMP system; or 4) inhibition through interference with gastrin release or gastrin activity. Because certain PGs have these inhibitory effect on gastric secretions, it is possible that they can be used clinically in the treatment of peptic ulcers.
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PMID:Prostaglandins and gastric secretion. 1226 11