Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P00790 (PGA)
 2,475 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We investigated the properties of tensile strength for the following suture materials: Polyglycolic acid (2. and 3.generation), Polyglactin 910 (3.generation) and Polydioxanon. They were situated within human large bowels for 10 to 12 days and investigated in a controlled experimental procedure. The decrease of the tensile strength in the human large bowel is significantly slower for polydioxanon suture (PDS) than for PGA (2. and 3.generation) and Polyglactin 910 (3.generation) suture. As PDS-suture are primarily less tractable than the others, there is no significant difference of tractability between all sutures after 11 days of implantation within the human colon. For PGA (3.generation) and Polyglactin 910 we found a strong loss of tractability after 10 to 12 days. In a second experimental series tensile strength, knot breaking security and knot holding capacity were tested in a tensiometer for absorbable suture materials with 3 and 6 parallel knots. The tensile strength was higher than the knot security for all sutures. Coated suture material (PGA and Polyglactin 910, both 3.generation) as well as the new monofile polydioxanon must be knotted manyfold for a secure knot position.
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PMID:[Polydioxanon (PDS)--a new monofilar synthetic, absorbable suture material. Tensile strength studies in a controlled clinical trial on the large intestine of humans and physical parameters in in vitro tests]. 640 80

The time requirement for endoscopic subperiosteal brow lift fixation is as little as 10-14 days. Many types of bioabsorbable fixation have been applied to this procedure, including bioabsorbable suture coupled with a bioabsorbable bone anchor, with excellent outcomes. Typically, the anchor and suture materials differ, each having their own hydrolytic strength loss profile. The dynamic relationship between the instantaneous state of degradation of the bone anchor and the suture components can affect fixation strength and failure mode, a poorly understood phenomenon. We examined the use of 2x5 mm PLLA-PGA (82:18) copolymer screws containing a suture eyelet in the head, paired with one of four types of bioabsorbable suture (2-0 and 3-0 Vicryl and 2-0 and 3-0 PDS-II), in a model system designed to mimic brow lift fixation. Constructs were inserted into a synthetic bone substrate and incubated in pH 7.4 buffer at 37 degrees C for up to 3 weeks, then loaded to failure. Initial failure loads were dependent upon suture size but not suture material, with 2-0 suture constructs (63-70N) failing at twice the load of the 3-0 suture constructs (30-35N). The following 3 week strength retentions were obtained: 40-55% for 2-0 and 3-0 Vicryl suture, 100% for 3-0 PDS-II suture, and 58% for 2-0 PDS-II suture constructs. The predominant failure mode was suture breakage at the knot, with the later intervals utilizing 2-0 PDS-II suture including some screw head failures. This suspension screw, when coupled with an appropriate suture, appears to have suitable mechanical properties for endoscopic brow lift fixation.
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PMID:In vitro characteristics of a bioabsorbable suspension screw and suture system for endoscopic brow lift surgery. 1741 97

Wound infection is a complication feared in surgery. The aim of this study was to develop new anti-infective coatings of surgical sutures and to compare the anti-microbial effectiveness and biocompatibility to the well-established Vicryl Plus. Synthetic absorbable PGA surgical sutures were coated with three different chlorhexidine concentrations and two different octenidine concentrations in combination with palmitic acid and lauric acid. Drug-release kinetics lasting 96 h were studied in phosphate-buffered saline at 37 degrees C. Anti-infective characteristics were determined by measuring the change in optical density of Staphylococcus aureus suspensions charged with coated sutures over time. Microorganisms adsorbed at the surface of coated sutures were assessed on blood agar plates and coated sutures eluted for 24 h were placed on bacterial lawns cultured on Mueller-Hinton plates to prove retained anti-microbial potency. A cell proliferation assay was performed to assess the degree of cytotoxicity. Anti-infective characteristics and biocompatibility were compared to Vicryl Plus. A coating technology for slow-release drug-delivery systems on surgical sutures could be developed. All coatings showed a continuous drug release within 96 h. Individual chlorhexidine and octenidine coated sutures showed superior anti-infective characteristics but inferior biocompatibility in comparison to Vicryl Plus. We conclude that the developed anti-infective suture coatings consisting of lipid-based drug-delivery systems in combination with antiseptics are highly effective against bacterial colonization in vitro; however, drug doses have to be adjusted to improve biocompatibility.
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PMID:New anti-infective coatings of surgical sutures based on a combination of antiseptics and fatty acids. 1962 81