Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P00790 (PGA)
 2,475 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 206 patients were subjected to operation for acute appendicitis through a pararectal laparotomy. Mersilene was used in 101 and polyglycolic acid (PGA, Dexon) in 105 patients as buried sutures for the closure of the abdominal wall, including the fascial layer. Wound complications developed after Mersilene in 23 and after PGA in 10 cases. PGA did not lead to an increased frequency of early wound infections. Granulomata or fistulae developed after Mersilene in 18 patients, but not in any of the cases in which PGA was used. Wound rupture and incisional hernia did not occur in any of the patients in the two groups.
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PMID:A comparison of Mersilene and polyglycolic acid sutures in pararectal abdominal wounds after appendectomy. 103 60

Monofilaments of the absorbable synthetic thread Dexon made from PGA have properties similar to nylon 10-0. Experiments with intra-lamellar implantation of the monofilament in rabbit corneas showed the same good material tolerance as nylon 10-0. Perforating corneal wounds were closed with interrupted and running sutures from PGA monofilaments, respectively. One week post-operatively, increased intraocular pressure caused a wound rupture but not a thread rupture. Two weeks post-operatively an increased intraocular pressure of more than 300 mm Hg could no longer rupture the wound. Slit lamp and histological examinations revealed symptoms of absorption after the second week. According to our findings, PGA monofilaments may be suitable for corneal surgery in patients.
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PMID:Animal experiments on an absorbable synthetic thread made of polyglycolic acid (PGA) in corneal surgery. 109 29

Polyglycolic acid sutures were used in 239 cases of intraocular surgery (164,6-0 size, 75, 7-0 size). Most of these (226) were cataract extractions. The results were excellent, with minimal complications. The 6-0 suture was somewhat stiff and associated with some tissue drag. The 7-0 size overcame these deficiencies and was considered the closest approach to date to the ideal absorbable suture. In addition, these appears to be an inhibition to bacterial penetration by PGA.
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PMID:Further use of polyglycolic acid (Dexon) sutures in cataract and other intraocular surgery. 111 10

6-0 Dexon (polyglycolic acid-PGA) suture was used in 30 eyes of 25 patients in surgical procedures which included cataract extraction, strabismus surgery, and ocular plastic surgery. The suture was found to hold the wound firmly, was not absorbed prematurely, was absorbed completely at a predicted time, was relatively easy to use although the knots were large, did not cause any infection or undue tissue reaction, and did not result in any wound dehiscence or vitreous loss.
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PMID:Evaluation of Dexon suture in ophthalmic surgery. 114 1

The limitations of catgut, which has been the only available absorbably suture material for surgical work are well known. In the present study, catgut and PGA (Dexon) are compared in 123 patients undergoing neck surgery with respect to wound complications. Dexon appears to offer a favourable alternative since this synthetic, absorbable suture material produces fewer early tissue reactions.
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PMID:Polyglycolic acid (PGA, Dexon) sutures in neck surgery. 118

The ultra-high-strength, self-reinforced (SR) absorbable polymeric composites, consisting of reinforcement elements, like fibers, and of matrix polymer which have the same chemical element composition as reinforcement, were defined. A method to manufacture self-reinforced, absorbable polyglycolide (SR-PGA) rods of polyglycolide sutures (Dexon) by sintering them partially together at elevated temperature and pressure was presented. The rods with nominal diameters of 1.5 mm, 2.0 mm, 3.2 mm, and 4.5 mm showed initial bending modulus and strength values of 8-15 GPa and 220-405 MPa, respectively. Their initial shear strengths were 165-255 MPa. The smallest rods (diam. 1.5 mm) lost their mechanical strength after implantation in the subcutis of rabbits in 4-5 weeks while the thickest rods retained their strength over 8 weeks. The ultra-high-strength SR-PGA rods were concluded to be suitable for fixation of cancellous bone fractures, osteotomies, and epiphyseal plate fractures where the fixation is not exposed to excessive mechanical stresses and where the loads are predominantly of a shear nature.
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PMID:Ultra-high-strength absorbable self-reinforced polyglycolide (SR-PGA) composite rods for internal fixation of bone fractures: in vitro and in vivo study. 185 Apr 29

Since 1987 absorbable PGA-mesh (Dexon) has been used as a pad for mattress sutures and as remaining tamponade in surgery of the liver and spleen. In 25 cases atypical resections of liver tumors have been performed using PGA-mesh to secure mattress sutures. Blood loss was below 500 cm3 in all cases, operating time was decreased and no infection was seen. Six times this technique was also used in cases with splenic trauma. In all patients the organ could be preserved. In 10 patients with severe trauma of the liver PGA-mesh was successfully used as a remaining tamponade. Also in these cases no infection occurred although 50 mesh had been implanted in one case.
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PMID:[Polyglycolic acid mesh in surgery of the liver and spleen]. 217 91

Tensile strength of poly(glycolic acid) suture (PGA) of size 2-0 was examined as a function of three pH levels, 5.25, 7.44, and 10.09 of the buffer. Cord and yarn grip was used to eliminate grip-induced failure of breaking strength tests. It was found that Dexon sutures degraded significantly faster in pH = 10.09 buffer than the other two lower pH buffers. There was no significant difference in degradation rate at pH = 5.25 and 7.44. At 7 days, PGA sutures lost almost half of its original tensile strength at pH = 10.09, while the same sutures still remained more than 95% of their original breaking strength at buffers of pH = 5.25 and 7.44. After 21 days, no trace of sutures could be detected in the buffer of pH = 10.09 while about 20% strength still remained in the buffers of pH = 7.44 and 5.25. Cage effect in the crystalline phase and pH dependent hydrogen bonding were introduced to explain the difference in degradation phenomenon of PGA at buffers of various pH.
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PMID:The in-vitro degradation of poly(glycolic acid) sutures--effect of pH. 627 45

We investigated the properties of tensile strength for the following suture materials: Polyglycolic acid (2. and 3.generation), Polyglactin 910 (3.generation) and Polydioxanon. They were situated within human large bowels for 10 to 12 days and investigated in a controlled experimental procedure. The decrease of the tensile strength in the human large bowel is significantly slower for polydioxanon suture (PDS) than for PGA (2. and 3.generation) and Polyglactin 910 (3.generation) suture. As PDS-suture are primarily less tractable than the others, there is no significant difference of tractability between all sutures after 11 days of implantation within the human colon. For PGA (3.generation) and Polyglactin 910 we found a strong loss of tractability after 10 to 12 days. In a second experimental series tensile strength, knot breaking security and knot holding capacity were tested in a tensiometer for absorbable suture materials with 3 and 6 parallel knots. The tensile strength was higher than the knot security for all sutures. Coated suture material (PGA and Polyglactin 910, both 3.generation) as well as the new monofile polydioxanon must be knotted manyfold for a secure knot position.
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PMID:[Polydioxanon (PDS)--a new monofilar synthetic, absorbable suture material. Tensile strength studies in a controlled clinical trial on the large intestine of humans and physical parameters in in vitro tests]. 640 80

The loss of breaking strength and elasticity of five absorbable suture materials (polydioxanone [PDS-II], polyglycolic acid [PGA], polyglactin 910 [PG-910], polyglyconate [GTMC], and chromic gut) after in vitro incubation in sterile, Escherichia coli- and Proteus mirabilis-inoculated canine urine was studied. Biomechanical testing, in a controlled environment, was performed during the 28-day study period. Polydioxanone and chromic gut retained greater than 90% of their original strengths after 28 days of incubation in sterile urine and 87% of original strengths in E. coli-inoculated urine. Polyglyconate retained 24% and 18% of original strength, respectively, after incubation in sterile and E. coli-inoculated urine for 28 days. Polyglycolic acid and PG-910 retained less than 30% of original strength in sterile urine and only 7% in E. coli-inoculated urine after 21 days of incubation. In P. mirabilis-inoculated urine, loss of tensile strength and elongation was significant for all suture materials. Polyglycolic acid and PG-910 lost all strength after 24 hours of incubation. Polydioxanone lost all strength after 7 days of incubation, whereas GTMC retained 19% at day 7. Chromic gut retained 78% at day 7 and 16% after 21 days of incubation, however, the absence of normal phagocytic destruction of chromic gut in this in vitro study may have artificially elevated these values. In sterile urine with chemically modified pH, loss of strength and elongation was greater in alkaline urine than in neutral or acidic urine for all types of suture materials.
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PMID:In vitro loss of tensile strength and elasticity of five absorbable suture materials in sterile and infected canine urine. 836 3


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