Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P00790 (PGA)
 2,475 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From today's point of view it is not possible to transfer the designs of metal implants in orthopaedic surgery to biodegradable polymers. The attempt of a simple mimicry of metal implants for those made of polymers was condemned to fail from the very beginning. In this paper some fundamental limitations of implants made from biodegradable polymers (PGA and PLA) are experimentally demonstrated. Fixing devices adapted to the characteristic properties of polymers and adjusted to the specific therapeutic problems have to be developed. The creation of new implant devices made of biodegradable polymers depends on the influence of manufacturing processes, composite materials, fibre reinforcement, coating, specific erosion processes and the development of new implant designs. The basis for a new implant philosophy is discussed.
 ...
PMID:New implant designs for bioresorbable devices in orthopaedic surgery. 1014 29

We demonstrate here the formation of compartmentalized polymersomes with an internal "gelly" cavity using an original and versatile process. Nanosize polymersomes of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA), formed by a solvent displacement method are encapsulated with a rough "cytoplasm mimic" in giant polymersomes of poly(butadiene)-b-poly(ethylene oxide) PB-b-PEO by emulsion-centrifugation. Such a system constitutes a first step toward the challenge of structural cell mimicry with both "organelles" and "cytoplasm mimics". The structure is demonstrated with fluorescence labeling and confocal microscopy imaging with movies featuring the motion of the inner nanosize polymersomes in larger vesicles. Without "cytoplasm mimic", the motion was confirmed to be Brownian by particle tracking analysis. The inner nanosize polymersomes motion was blocked in the presence of alginate, but only hindered in the presence of dextran. With the use of such high molecular weight and concentrated polysaccharides, the crowded internal volume of cells, responsible for the so-called "macromolecular crowding" effect influencing every intracellular macromolecular association, seems to be efficiently mimicked. This study constitutes major progress in the field of structural biomimicry and will certainly enable the rise of new, highly interesting properties in the field of high-added value soft matter.
 ...
PMID:Polymersomes in "gelly" polymersomes: toward structural cell mimicry. 2214 33