Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
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Target Concepts:
Gene/Protein
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Enzyme
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Query: UNIPROT:P00790 (
PGA
)
2,475
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Over a period of 7 years (1987-1994), 24 cases of
osteochondritis dissecans
of the knee were treated with self-reinforced polyglycolic acid (SR-PGA) and polylactic acid (SR-PLLA) rods. Rods measuring 1.1 mm, 1.5 mm and 2 mm in diameter, and 20-40 mm in length were used in the fixation of the fragment depending on the size of the lesions. There were 23 patients with osteochondritis dessicans in the medial and 1 in the lateral femoral condyle. The average age of the patients was 25 years (range: 16-48). Follow-up was for 3.3 years (range: 1-7.6). There were 6 lesions in situ, 3 early separations, 11 were partially detached, and there were 4 loose bodies. SR-
PGA
rods were used in 12 patients, SR-PLLA rods in 11 patients, and both SR-
PGA
and SR-PLLA rods in 1 patient. The rod in each case was inserted subchondrally and in 9 cases arthroscopically, using a special instrument. In our study, the clinical result was excellent in 13 patients, good in 6, fair in 1 and poor in 4. On radiological assessment the fragment had healed in 19 cases. Synovitis occurred in 1 patient in the SR-
PGA
group (1/13): the effusion continued for 6 months postoperatively but, after treatment by needle aspiration, there were no symptoms at follow-up 4.2 years later. We conclude that SR-
PGA
and SR-PLLA rods can be used intra-articularly for the adequate fixation of
osteochondritis dissecans
.
...
PMID:Osteochondritis dissecans of the knee fixed with biodegradable self-reinforced polyglycolide and polylactide rods in 24 patients. 949 41
Most of the metallic devices have to be removed, treating
osteochondritis dissecans
lesions. This animal study describes the biological and mechanical behavior of screws and pins, made of commercially available
PGA
/PLA and PLA96 and metallic screws and pins, used for fragment fixation. A sham operation served as control. A tissue reaction with cavity formation was observed around every
PGA
/PLA screw, beginning at 12 weeks following insertion, in contrast to once around a PLA96 screw (p < 0.001), once around one of the 16
PGA
/PLA pins and never around those, made of PLA96 (no significance). Disintegration of the
PGA
/PLA devices started 6 weeks following implantation against 34 weeks for the PLA96 implants. The gap between the fragment and the recipient cartilage disappeared only in the sham group. Many fragments of
PGA
/PLA material were found in the synovia, in contrast with just a few fragments in the PLA96 group, causing a mild cellular reaction. No polymer particles were found in the draining lymph nodes at any interval. In conclusion, the tested biodegradable screws should not be used for fragment fixation in the treatment of
osteochondritis dissecans
. Either an undesirable tissue reaction can be expected (PGAPLA), or, because of the slow degradation (PLLA), a screw might damage the opposite cartilage during weight bearing. Two biodegradable pins provide a safe rotational stability and should be combined with one metallic screw, providing compression. This screw has to be removed before loading the limb to prevent cartilage wear of the opposite tibia plateau.
...
PMID:Should in the treatment of osteochondritis dissecans biodegradable or metallic fixation devices be used? A comparative study in goat knees. 1747 89
The Patlak graphical analysis (
PGA
REF
) for quantification of irreversible tracer binding with a reference tissue model was approximated by a dual time point imaging approach (DTP
REF
). The DTP
REF
was applied to 18 [
18
F]-FDOPA brain scans using the occipital cortex as reference region (DTP
OCC
) and compared to both
PGA
OCC
and striatal-to-occipital ratios (SOR). Pearson correlation analysis and Bland-Altman plots showed an excellent correlation and good agreement between DTP
OCC
and
PGA
OCC
, while correlations between SOR and
PGA
OCC
were consistently lower. Linear discriminant analysis (LDA) demonstrated a similar performance for all methods in differentiating patients with Parkinson's disease (PD) from healthy controls (HC). Specifically for [
18
F]-FDOPA brain imaging, these findings validate DTP
OCC
as an approximation for
PGA
OCC
, providing the same quantitative information while reducing the acquisition time to two short static scans. For PD patients, this approach can greatly improve patient comfort while reducing motion artifacts and increasing image quality. In general, DTP
REF
can improve the clinical applicability of tracers with irreversible binding characteristics when a reference tissue is available.
...
PMID:Dual time point method for the quantification of irreversible tracer kinetics: A reference tissue approach applied to [
18
F]-FDOPA brain PET. 2815 11
