Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P00750 (
PLA
)
16,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aim
To investigate the
RBP4
/Lp-
PLA
2
/Netrin-1 signal regulation of cognitive function impairment in diabetic nephropathy patients with silent cerebral infarction (SCI).
Methods
One-hundred patients newly diagnosed with diabetic nephropathy patients were included. The patients were divided into SCI group and NSCI group according to the radiological data. The degrees of cognitive dysfunction were evaluated. Serum
RBP4
concentrations were determined by ELISA and protein expressions of Lp-
PLA
2
and Netrin-1 were determined by Western Blot.
Results
Compared with NSCI group, the cognitive function of patients in SCI group was impaired, the concentrations of
RBP4
and the expressions of Lp-
PLA
2
and Netrin-1 increased (P<0.05).
RBP4
concentrations were positively correlated with the cognitive dysfunction of SCI patients. Moreover, there existed a regression correlation between them.
Conclusion
RBP4
may be used as a predictive factor of diabetic nephropathy patients complicated with SCI and is positively correlated with cognitive dysfunction.
RBP4
/Lp-
PLA
2
/Netrin-1 pathway activation may be one of the occurrence mechanisms in diabetic nephropathy complicated with SCI.
...
PMID:RBP4/Lp-PLA2/Netrin-1 signaling regulation of cognitive dysfunction in diabetic nephropathy complicated with silent cerebral infarction. 2870 53
