Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P00750 (PLA)
 16,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new poly(L-lactide) (PLA)-degrading actinomycete, Kibdelosporangium aridum, degraded more than 97 mg out of 100 mg added high molecular weight PLA film (Mn: 3.4 x 10(5)) within 14 d in liquid culture. L-Lactic acid, the monomeric degradation product of PLA, was totally assimilated by the strain. In solid culture, many distinct grooves formed by the morphology of filamentous microorganisms on the surface of a PLA film were observed by scanning electron microscopy.
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PMID:Poly(L-lactide) degradation by Kibdelosporangium aridum. 1471 19

Paclitaxel and poly (L-Lactic acid) (PLA) were co-precipitated to form micro and submicron particles in a manner similar to that used in the supercritical antisolvent with enhanced mass transfer (SAS-EM) process. As compared with conventional processes, a major advantage of supercritical CO(2) as an antisolvent in the SAS-EM process is the effective removal of residual organic solvents. In this work, the organic phase was sprayed into supercritical CO(2) (for CO(2), Tc=31.1 degrees C, Pc=73.8 bar) from a 500 microm ID capillary nozzle. Ultrasonic vibration with an amplitude of 0 to 120 microm (from a 3/8'' tip diameter titanium probe) was employed in the high pressure vessel during the antisolvent process to provide enhanced mixing between the solvent and antisolvent phases. The role and effects of ultrasonication on the properties of the resulting particles were studied. When no ultrasonication was applied, micrometer-sized particles were obtained. When ultrasonication was applied, more uniform particles in the submicron size range were obtained. The size of the particles was found to vary with the ultrasonic vibration amplitude. Encapsulation efficiencies up to 83.5% and controlled release of paclitaxel for more than 30 days were achieved with the particles fabricated in this study.
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PMID:Supercritical antisolvent production of biodegradable micro- and nanoparticles for controlled delivery of paclitaxel. 1805 7