Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P00750 (
PLA
)
16,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Contrast agents have been utilized for x-ray imaging to visualize blood vessels. Triiodobenzene derivatives are known contrast agents yet have not been formulated in a nanoparticle form for the purpose of enhancing the contrast of cancer tissues. In this study, experiments to encapsulate
2,4,6-triiodophenol
in a polymer matrix were designed. Spherical NPs made of
PLA
, PLGA,
PLA
-TPGS, PLGA-TPGS and TPGS-FOL, were synthesized and characterized. Using the oil-in-water single-emulsion technique, the effect of several experimental parameters such as sonication power, ratio of
2,4,6-triiodophenol
/polymer, type and concentration of emulsifier, and polymer type has been studied. A good morphology of polymer NPs with entrapped
2,4,6-triiodophenol
was successfully obtained however the encapsulated iodine was in the range of 5 to 26%.
...
PMID:Polymer nanoparticles containing 2,4,6-triiodophenol: a potential contrast medium for medical imaging. 2512 26
