Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P00750 (PLA)
 16,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Leukocyte-derived arachidonate products peptido-leukotrienes have been shown to induce coronary constriction and platelet aggregation. As such, leukocytes may have a role in coronary thrombosis and coronary re-occlusion following thrombolysis. In the present study, we examined the effects of tissue-plasminogen activator (t-PA, 0.75 mg/kg over 20 minutes) given after either saline or FPL-55712 (2 mg/kg), a peptido-leukotriene receptor antagonist, in dogs with electrically-induced coronary thrombosis. Peripheral blood neutrophil number and superoxide anion generation increased (P less than 0.01) during formation of thrombus and subsequent t-PA administration in saline-treated dogs. FPL-55712 pretreatment attenuated (P less than 0.05) the increase in number of and superoxide anion generation by neutrophils. However, frequency of thrombolysis, duration of restored flow and re-occlusion rates were similar (P-NS) in both groups of dogs. This study shows that FPL-55712 does not modulate the thrombolytic potential of t-PA even though it decreases neutrophil activation in response to myocardial ischemia.
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PMID:Leukotriene-receptor antagonist FPL-55712 and t-PA-induced thrombolysis in canine coronary thrombosis. 216 Jul 45

1. Acute release of plasminogen activator (PA) was studied in rat isolated hindleg system perfused with Tyrode solution. 2. Leukotriene C4 (LTC4) and LTD4 dose-dependently induced the release of PA, which plateaued at 160 nmol l-1 and 200 nmol l-1, respectively. The amount of PA released was about 1 iu ml-1. The effects of LTC4 and LTD4 were not additive. 3. The PA released was identified as tissue-type PA (t-PA) by quenching experiments using anti-human t-PA IgG, by fibrin autography, and by the dependence of its activity on the presence of soluble fibrin. 4. LTE4 (300 and 450 nmol l-1) and 5-hydroxy-eicosatetraenoic acid (600 nmol l-1) did not induce any t-PA release in the perfusion system used. 5. Release of t-PA induced by LTC4 and LTD4 was inhibited by the leukotriene-receptor antagonist FPL 55712 (10 mumol l-1), whereas FPL 55712 did not inhibit t-PA release induced by platelet-activating factor (Paf-acether). 6. In vivo LTC4 and LTD4 (2 micrograms kg-1 i.v.) also induced an acute increase of t-PA activity in rat blood as evidenced by decreased blood clot lysis times. 7. Prostaglandin E1 and E2, prostacyclin and the stable prostacyclin analogue ZK 36374 at concentrations of 0.1-3.0 mumol l-1 induced little or no t-PA release.
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PMID:Release of tissue-type plasminogen activator is induced in rats by leukotrienes C4 and D4, but not by prostaglandins E1, E2 and I2. 312 47

Among the 3D-printing technologies, fused deposition modeling (FDM) represents a promising route to enable direct incorporation of the battery within the final 3D object. Here, the preparation and characterization of lithium iron phosphate/polylactic acid (LFP/PLA) and SiO2/PLA 3D-printable filaments, specifically conceived respectively as positive electrode and separator in a lithium-ion battery is reported. By means of plasticizer addition, the active material loading within the positive electrode is raised as high as possible (up to 52 wt.%) while still providing enough flexibility to the filament to be printed. A thorough analysis is performed to determine the thermal, electrical and electrochemical effect of carbon black as conductive additive in the positive electrode and the electrolyte uptake impact of ceramic additives in the separator. Considering both optimized filaments composition and using our previously reported graphite/PLA filament for the negative electrode, assembled and "printed in one-shot" complete LFP/Graphite battery cells are 3D-printed and characterized. Taking advantage of the new design capabilities conferred by 3D-printing, separator patterns and infill density are discussed with a view to enhance the liquid electrolyte impregnation and avoid short-circuits.
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PMID:Three-Dimensional Printing of a LiFePO4/Graphite Battery Cell via Fused Deposition Modeling. 3179 14