Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P00750 (
PLA
)
16,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
(E,E)-1,4-Diphenylbutadiene derivatives were synthesized by utilizing the Stobbe reaction of
dimethyl succinate
as a key step. Their stereoisomers were also synthesized stereoselectively by means of the cross-coupling reaction of the vinylstannanes and the vinylbromides, which were obtained from the propiolic acid esters by stereoselective hydrostannation, as a key step. To discover novel stimulators of fibrinolysis in vascular endothelial cells, the synthesized compounds were added to cultured bovine endothelial cells to determine the activity of the
plasminogen activator
in the conditioned medium. Of the synthesized compounds, three compounds were found to stimulate the activity of the
plasminogen activator
in endothelial cells. In addtition, these compounds inhibited thrombus formation in a rat model of venous thrombosis.
...
PMID:Synthesis of 1,4-diphenylbutadiene derivatives: novel inducer of tissue-type plasminogen activator (t-PA) in cultured bovine endothelial cells. 1713 4
