Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P00750 (
PLA
)
16,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Thrombospondin (
TSP-1
) is a large glycoprotein secreted by platelets and synthesized by many cell types, including endothelial and tumor cells. Although controversy exists about the biological function of
TSP-1
, the following observations suggest that
TSP-1
may potentiate tumor progression. (1) Tumor metastases in mice are promoted by
TSP-1
and inhibited by anti-
TSP-1
antibodies. (2)
TSP-1
promotes tumor cell adhesion, migration and invasion. (3)
TSP-1
promotes angiogenesis in the rat aorta model. (4)
TSP-1
up-regulates the
plasminogen activator
system through a mechanism involving the activation of TGF-beta 1. (5) Human tumors express increased levels of the CSVTCG-specific
TSP-1
receptor. (6) Tumor stroma is enriched in
TSP-1
. (7) Cancer patients have high blood levels of
TSP-1
. (8) Poor patient survival correlates with a higher expression of the CSVTCG-specific
TSP-1
receptor on tumor cells. In this paper we discuss the evidence that
TSP-1
promotes tumor progression and present a hypothetical scheme for its mechanism of action.
...
PMID:The role of thrombospondin-1 in tumor progression and angiogenesis. 859 67
