Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P00750 (PLA)
 16,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic prostatitis (CP) is a common disease among adult men. It can result in male infertility mainly by alternating the semen quality, volume, pH, component, viscosity and liquefaction. There seems to be a strong association between CP and semen delayed liquefaction. Researches on the mechanism of semen delayed liquefaction resulting from CP mainly focus on the proteolytic ferment, plasminogen activator, prostate acid phosphatase, tissue factor, lack of zinc, and pH. This article briefly reviews the progress in these aspects.
 ...
PMID:[Progress in the studies of semen delayed liquefaction from chronic prostatitis]. 1730 37

Armillaria ostoyae is a phytopathogen infecting coniferous trees. Fruiting bodies of this basidiomycete contain high phospholipase A(1) (PLA(1)) activity. In this paper, the role of phospholipid-deacylating activity, which was also detected in fruiting bodies of other basidiomycetes, in the fungal lipid metabolism is elucidated. For A. ostoyae the occurrence of PLA(1) activity is shown to be restricted to the late reproductive phase, correlating with the release of mature spores. Specific expression in the spore-producing tissue provides evidence for the involvement of PLA(1) in spore formation. Based on lipid analysis, the degradation of membrane phospholipids in this tissue can be ascribed mainly to PLA(1) activity because other enzymes such as phospholipases C and D, triglyceride lipase and phosphatidic acid phosphatase had only low activities. A concomitant increase in the concentration of fatty acids and their anabolites (di- and triglycerides), which are used as storage lipids in the developing fungal spore cells, was observed. Therefore, PLA(1) contributes to the formation of spores by providing membrane constituents as a source of fatty acids.
 ...
PMID:Phospholipid acylhydrolases trigger membrane degradation during fungal sporogenesis. 2168 50

This study was undertaken to investigate the effect of triptolide (TP) on male rats after oral polymer nanoparticle delivery (TP-loaded poly(D,L-lactic acid) nanoparticles, TP-PLA-NPs). Free TP and TP-PLA-NPs were administered orally at doses of 0.2 and 0.6 mg/kg for 15 days and rats were sacrified at end of the dosage period. All rat testes were weighed, fructose content and activity of acid phosphatase (ACP) were assayed, and testis tissues were observed histopathologically. Testis weight, testis index, ACP activity, and fructose content of the treated animals were lower than those of the control group. Moreover, ACP activity and fructose content were markedly decreased for free TP of 0.6 mg/kg in comparison to the same dose of TP-PLA-NPs. Obvious pathological changes were not observed for a dose of 0.2 mg/kg free TP and TPPLA-NPs at the end of 15 days. At a dose of 0.6 mg/kg, however, free TP caused more serious damage to the testes than TP-PLA-NPs. These results revealed that TP-PLA-NPs might decrease the testis toxicity of TP because TP was slowly released from polymer nanoparticles. Further research on this mechanism of abated toxicity is in progress.
 ...
PMID:Preliminary research on abating rat testicle toxicity due to triptolide after oral polymer nanoparticle delivery. 2250 71


<< Previous 1 2 3