Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P00750 (
PLA
)
16,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Localization of
t-PA
, u-PA, PAI-1, PI and TGF-beta within tumors was examined immunohistologically in 31 patients with squamous cell carcinoma (SCC) of the head and neck, and correlations between the localization of these factors and
local cancer
infiltration, tumor size or cervical lymph node metastasis were investigated. The results revealed that u-PA, PAI-1 and PI tend to stain more intensely in infiltrating tumors than in peripheral connective tissue or normal epithelium, whereas neither
t-PA
nor TGF-beta showed any such tendency. Not all of these fibrinolytic factors participated in lymph node metastases or influenced tumor size in head and neck SCCs. These results suggest a disorder of fibrinolytic systems in carcinoma cells and that u-PA plays a part in the infiltration of head and neck SCCs by degenerating connective tissue.
...
PMID:Relationship between head and neck squamous cell carcinomas and fibrinolytic factors. Immunohistological study. 890 83
In this study, we formulated a rIL-2 loaded sustained-release dextran/PLGA-
PLA
core/shell microsphere, mimicking the paracrine mechanisms of cytokine action, to investigate its local antitumor efficacy. The presented microspheres were formed in two steps: rIL-2 was firstly loaded into dextran particles to keep its bioactivity by a unique method of stabilizing aqueous-aqueous "emulsion"; subsequently, the particles were encapsulated into poly(dl-lactide-co-glycolide)/polylactic acid (PLGA/
PLA
). A stable sustained release behavior in vitro was achieved for a period of about 25 days. In the subcutaneous colon carcinoma BALB/c mice models, a single dose of microspheres was introtumorally administrated and compared with multiple doses of rIL-2 solution to investigate the long acting effect of microspheres on tumor. The animal experiments showed the local efficacy at tumor site mediated by rIL-2 from a single dose of microspheres was better than that of multiple rIL-2 solution injections. Based on the experimental results, we conclude that rlL-2 loaded sustained-release dextran/PLGA-
PLA
core/shell microspheres represent a promising approach for
local cancer
treatment in animals.
...
PMID:Local antitumor effects of intratumoral delivery of rlL-2 loaded sustained-release dextran/PLGA-PLA core/shell microspheres. 2362 84
The application of the biphasic release profile furnished by electrospun polyblend nanofibers for
local cancer
treatment was investigated. By adjusting the weight ratio of the hydrophilic polymer (poly(ethylene oxide), PEO) and hydrophobic polymer (poly(l-lactide),
PLA
), PEO
10
-
PLA
90
fibers with typical biphasic release kinetics were successfully prepared. Due to their unique release profile, PEO
10
-
PLA
90
fibers can quickly access the tumor site in vivo at a high drug content within 1 h and keep at a high level for longer than two weeks. In vivo antitumor and safety studies demonstrated that PEO
10
-
PLA
90
fibers can achieve optimized
local cancer
treatment efficacy and avoid undesired adverse reactions. The biphasic drug release profile provided by the polyblend electrospun technology was proven to be a new conception for local chemotherapy.
...
PMID:Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment. 2924 57
