Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P00750 (
PLA
)
16,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The production of the extracellular protease,
plasminogen activator
, in relationship to growth in semi-solid medium and tumorigenicity has been studied in Syrian hamster embryo and strain 2 guinea-pig embryo cell culture models of
chemical carcinogenesis
. Whereas normal hamster and guinea-pig embryo cells had negligible levels of
plasminogen activator
, neoplastically transformed cells derived from cultures exposed to chemical carcinogens had high levels of
plasminogen activator
and grew as progressively enlarging colonies in soft agar. The development of
plasminogen activator
secretion in relation to neoplastic transformation was further studied in the guinea-pig cells where the latent period between carcinogen exposure and neoplastic transformation ranged from 4 months to more than one year. The production of
plasminogen activator
in this system also exhibited a long latent period, and acquisition of extracellular
plasminogen activator
correlated temporally with growth in agar and tumorigenicity. Plasminogen activator and growth in semi-solid agar in concert are useful markers for identification of neoplastic cells transformed in culture following exposure to a chemical carcinogen.
...
PMID:Plasminogen activator synthesis accompanying chemical carcinogen-induced in vitro transformation of Syrian hamster and guinea-pig fetal cells. 719 61
