Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P00750 (PLA)
 16,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A readily accessible and robust Zr-NHC complex was found to polymerize rac-lactide in a highly controlled, living and stereoselective manner to afford heterotactic PLA.
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PMID:A robust zirconium N-heterocyclic carbene complex for the living and highly stereoselective ring-opening polymerization of rac-lactide. 2225 12

The present paper describes an overview of a novel family of tridentate NHC pincer ligand in which two phenoxide moieties are directly connected to the nitrogen atoms of a central N-heterocyclic carbene. It was envisioned that such a structure might be suitable for coordination to a variety of metal centers across the periodic table, including oxophilic metals. Various metal complexes bearing such ligand are indeed readily accessible in high yields via straightforward routes. Interestingly, a robust zirconium-NHC complex was found to polymerize rac-lactide in a highly controlled, living and stereoselective manner to afford heterotactic PLA.
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PMID:Combining NHC bis-phenolate ligands with oxophilic metal centers: a powerful approach for the development of robust and highly effective organometallic catalysts. 2543 90