Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P00750 (PLA)
 16,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The case of a 63-year-old woman with a Bjork-Shiley mitral valve prosthesis who developed acute thrombosis of mitral prosthesis and acute pulmonary edema is described. Full clinical success was achieved with medical therapy with tissue-type plasminogen activator. The dosage of drug was titrated by serial echo-Doppler examinations of prosthetic structures and functional area. A low-dose (60 mg over 1 hour) of tissue-type plasminogen activator was sufficient to obtain thrombus resolution. Embolic or hemorrhagic complications were absent. This is the first report of successful use of Doppler echocardiography titrated low-dose of tissue-type plasminogen activator for acute thrombosis of mitral prosthetic valve.
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PMID:[The resolution of a mitral valve prosthesis thrombosis with low-dose plasminogen tissue activator and the role of Doppler echocardiographic monitoring]. 807 30

Prosthetic valve thrombosis is a rare and dreaded complication of patients with mechanical valves, particularly those in the mitral position. A 45-year-old female with status post prosthetic mitral valve replacement was admitted to the hospital with acute pulmonary edema. Echocardiography showed mitral valve thrombosis which was treated with tissue plasminogen activator (t-PA). During t-PA infusion she developed acute inferoposterior myocardial infarction. Coronary angiography showed normal coronary arteries. Presented case had acute inferoposterior myocardial infarction secondary to coronary emboli after the successful thrombolytic treatment of prosthetic mitral valve thrombosis.
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PMID:A rare cause of myocardial infarction: acute inferoposterior myocardial infarction after successful intravenous thrombolytic treatment of mechanical mitral prosthetic valve thrombosis. 1617 40