Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P00750 (PLA)
 16,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report on 1,082 cases of malignant lymphomas from the files of the Department of Pathology, Chinese PLA General Hospital, Beijing. We found non-Hodgkin's lymphomas (NHL) in 980 cases (91%) and Hodgkin's disease (HD) in the remaining 102 cases (9%). Among the NHL, the diffuse type was seen in 955 cases (97.4%) and the follicular type in 25 cases (2.6%). Among the diffuse NHL, the pleomorphic type was most frequently found (263 cases or 26.8%), followed in frequency by the mixed small and large cell (163 cases or 16.6%). The large-cell cleaved and noncleaved immunoblastic was found in 139 cases (14.2%), small cleaved cell in 132 cases (13.5%), lymphoblastic convoluted and nonconvoluted in 72 cases (7.3%), the small lymphocytic type in 128 cases (13.1%), plasmacytoid type in 40 cases (4.1%), and Burkitt type in 18 cases (1.8%). Using immunohistocytochemistry, we found T-cell lymphoma in 53% and B-cell lymphoma in 47% of cases. The distinctive differences of malignant lymphomas types between China and Western countries suggest the possibility of a relationship to environmental factors.
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PMID:Malignant lymphomas in Beijing. 146 16

Understanding of the leukemic evolution of human non-Hodgkin's lymphomas is hindered by the lack of appropriate animal models. For this purpose, a highly leukemic cell line NQ22, derived from a MCF 247 murine leukemia virus (MuLV)-induced murine T-cell lymphoma, was established, and its preliminary characterization is described. The NQ22 cell line is easily transplantable subcutaneously (s.c.) into syngeneic AKR mice exhibiting early peripheral blood invasion and widespread dissemination with a leukemic pattern of infiltration. Such peculiar in vivo behavior is a stable phenotypic feature, probably determined genetically. Biological and differentiation characteristics of the NQ22 cell line were analyzed and compared to those of other non-leukemic T-lymphoma lines. In addition, no evidence of possible involvement of plasminogen activator (PA) enzymes and of their inhibitors (PAI) in the spreading ability of NQ22 cells was observed.
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PMID:Establishment and characterization of a leukemic murine cell line derived from MCF 247 MuLV-induced T-cell lymphoma. 215 41