Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P00750 (PLA)
 16,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A model of disseminated histoplasmosis in CBA/J mice was developed. Cultures of Histoplasma capsulatum from the spleens of infected mice suggested almost complete clearance of fungi by week 3. The adherent spleen cells from infected mice showed a 2- to 20-fold increase in fibrinolysis. The increase in activity was maximal around 1 to 2 weeks and disappeared after week 3 of infection, and this paralleled the progressively decreasing number of culturable fungi from the spleen. In vitro coculture of infected spleen cells or nylon wool-purified immune T cells and proteose peptone-induced macrophages resulted in increased fibrinolysis. Peritoneal exudate cells from infected mice also showed increased fibrinolysis. The addition of soluble antigen to an in vitro culture system resulted not only in an increase in fibrinolytic activity of peritoneal exudate cells derived from infected mice but also of proteose peptone-induced macrophages. These observations suggest that spleen and peritoneal macrophages from H. capsulatum-infected mice exhibit increased fibrinolysis which in turn is indicative of macrophage activation. The mechanism of activation occurs as a result of immunologically specific T cell-macrophage interaction and by the action of histoplasma products on the macrophages. The significance of these findings and the role of the plasminogen activator assay in studies of disseminated fungal infection are discussed.
 ...
PMID:Macrophage-related fibrinolysis in experimental disseminated histoplasmosis. 387 59

The utilization of polymer-based materials is quickly expanding. The enterprises of today are progressively seeking techniques to supplant metal parts with polymer-based materials as a result of their light weight, simple support and modest costs. The ceaselessly developing requirement for composite materials with new or enhanced properties brings about the preparation of different polymer mixes with various arrangements, morphologies and properties. Fused filament fabrication processes such as 3D-printing are nowadays shaping the actual pathway to a full pallet of materials, from art-craft to biomaterials. In this study, the structural and mechanical behavior of three types of commercially available filaments comprised of synthetic poly(acrylonitrile-co-butadiene-co-styrene) (ABS), poly(lactic acid) (PLA) and poly(lactic acid)/polyhydroxyalkanoate reinforced with bamboo wood flour composite (PLA/PHA BambooFill) were assessed through mechanical testing and optical microscopy, aiming to understand how the modifications that occur in the printed models with internal architecture are influencing the mechanical properties of the 3D-printed material. It has been determined that the material printed from PLA presents the highest compression strength, three-point bending and shock resistance, while the ABS shows the best tensile strength performance. A probability plot was used to verify the normality hypothesis of data for the tensile strength, in conjunction with the Anderson-Darling statistic test. The results of the statistic indicated that the data were normally distributed and that there is a marked influence of the internal architecture of the 3D-printed models on the mechanical properties of the printed material.
 ...
PMID:Influence of Internal Innovative Architecture on the Mechanical Properties of 3D Polymer Printed Parts. 3242 75