Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P00492 (hypoxanthine-guanine phosphoribosyltransferase)
 2,385 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
hypoxanthine-guanine phosphoribosyltransferase 2385
Mol 292
HPRT 253
Sep 189
AMP 158
X-linked 134
IMP 100
GMP 69
purine nucleoside phosphorylase 68
thymidine kinase 59
ATP 50
adenosine deaminase 50
GTP 44
fused 40
phosphoglycerate kinase 40
glucose-6-phosphate dehydrogenase 40
X-chromosome 39
adenosine kinase 37
xanthine oxidase 35
HAT 34
X-linked recessive 32
p53 31
hypoxanthine guanine phosphoribosyltransferase 29
housekeeping 29
hemoglobin 22
aprt 20
5'-nucleotidase 20
ATPase 18
lymphoid 15
cytochrome P450 14
glyceraldehyde-3-phosphate dehydrogenase 14
Gen 13
polypeptide 13
beta-actin 13
NAD 13
catalase 13
promyelocytic leukemia 12
ADP 12
erythroid 12
amidophosphoribosyltransferase 12
glycophorin A 11
superoxide dismutase 11
T cell receptor 11
cytokine 11
microsomal 11
thymus 10
glutathione S-transferase 10
adenylosuccinate synthetase 10
endonuclease 10
threonine 9
alpha-galactosidase 9
Adenosine deaminase 9
MCL 9
insulin 9
c-myc 9
guanine deaminase 9
alkaline phosphatase 8
AMP deaminase 8
DNA polymerase 8
telomeric 8
GSH 8
oxidoreductase 8
tyrosine hydroxylase 7
transferrin receptor 7
DNase I 7
methylguanine-DNA methyltransferase 7
XMP 7
anonymous 7
beta-globin 7
H2AX 7
ras 7
cryptic 7
Met 7
GDP 7
adenylate kinase 7
AHH 7
CYP1A1 7
nucleoside phosphorylase 6
XPD 6
IFN-gamma 6
more...
Disease
Lesch-Nyhan syndrome 636
cancer 226
carcinogenesis 116
tumor 95
hyperuricemia 93
gout 72
mental retardation 51
mental retardation 51
self-injurious behavior 43
lymphoma 40
leukemia 39
choreoathetosis 29
arthritis 28
enzyme deficiency 25
carcinoma 21
renal failure 20
neuroblastoma 18
xeroderma pigmentosum 18
nephrolithiasis 17
anemia 17
acute promyelocytic leukemia 16
Schistosoma mansoni 15
hepatocellular carcinoma 15
acute lymphoblastic leukemia 15
immunodeficiency 15
renal disease 14
cerebral palsy 13
genetic disorder 13
herpes simplex 13
autism 13
CEM 12
breast cancer 11
neurological disease 10
Epstein 10
malaria 9
mantle cell lymphoma 9
MCL 9
Down syndrome 9
tumorigenesis 9
developmental delay 8
GSH 8
acute renal failure 8
ATM 8
fragile X syndrome 8
chronic myeloid leukemia 8
Alzheimer's disease 8
fits 8
embryonal carcinoma 8
diabetes 7
lung cancer 7
adenocarcinoma 7
depression 7
malnutrition 7
infectious diseases 7
fibrosarcoma 7
urolithiasis 7
tuberculosis 7
Chagas 7
Hodgkin's disease 7
Fanconi 7
Tay-Sachs disease 7
acute myeloid leukemia 7
aggression 6
hypertension 6
MCF 6
neoplastic transformation 6
schizophrenia 6
melanoma 6
ADA deficiency 6
Parkinson's disease 6
Mycobacterium 6
skin cancer 6
inflammatory bowel disease 6
developmental disabilities 6
Kelley-Seegmiller syndrome 6
Huntington's disease 6
phenylketonuria 5
SDS 5
nephrocalcinosis 5
megaloblastic anemia 5
more...
Symptom
spasticity 30
dystonia 18
starvation 7
pain 7
athetosis 6
vomiting 6
chorea 4
seizures 4
anesthesia 3
tremor 3
hypotonia 3
hypertonia 2
dysarthria 2
abdominal pain 2
renal colic 2
weakness 2
clumsiness 2
ataxia 2
dyspnea 1
overweight 1
labored breathing 1
dysesthesia 1
hepatomegaly 1
dysuria 1
forgetfulness 1
muscle stiffness 1
lethargy 1
hyperoxia 1
acute stress 1
fatigue 1
splenomegaly 1
analgesia 1
myoclonus 1
hemoptysis 1
diarrhea 1
colic 1
HSA 1
chromosome marker 1
paresis 1
nausea 1
Decreased activity 1
sleepiness 1
collapse 1
flank pain 1
respiratory distress 1
stridor 1
Fluctuation 1
Drug
Mutagen 81
G418 16
BH4 13
lysine 10
caffeine 9
Adenosine deaminase 9
DNase I 7
IFN-gamma 6
Adriamycin 6
CSF 4
AZT 4
AZT 4
Asn 3
ACT 3
Acyclovir 3
Dermatol 3
Thioguanine 3
Etoposide 3
Nephron 3
THF 3
-deoxyadenosine 3
ascorbate 2
AGG 2
TAT 2
vitamin E 2
ICI 2
NADH 2
Neocarzinostatin 2
IFN-beta 2
IL-2 2
Rasburicase 2
Ethanol 2
nitroglycerin 2
Gel 2
Adozelesin 1
Dial 1
Reserpine 1
CTC 1
ETS 1
Deoxyadenosine 1
Ouabain 1
ddI 1
Febuxostat 1
Infliximab 1
6-Methylpurine 1
CaCl2 1
Hypaque 1
Kenyan 1
Mercaptopurine 1
CaCl2 1
Mycophenolic acid 1
Glutathione 1
Hypaque 1
Parkin 1
Cellulose acetate 1
Prednisone 1
TMX 1
FAD 1
Cytidine 1
Helium 1
CaCl2 1
ABC 1
Formycin B 1
AraC 1
BLM 1
CFT 1
Infliximab 1
AIC 1
Arsenic trioxide 1
ampicillin 1
Propidium 1
8-Azaguanine 1
KCL 1
Nitric Oxide 1
CTC 1
Bifidobacterium 1
Spectrum 1
Sorafenib 1
Spectrum 1
OMP 1
more...
Enzyme
hypoxanthine-guanine phosphoribosyltransferase 1475
adenine phosphoribosyltransferase 132
purine nucleoside phosphorylase 67
thymidine kinase 59
adenosine deaminase 52
adenosine deaminase 50
glucose-6-phosphate dehydrogenase 43
phosphoglycerate kinase 43
xanthine oxidase 34
adenosine kinase 32
IMP dehydrogenase 25
5'-nucleotidase 24
PRPP synthetase 21
glyceraldehyde-3-phosphate dehydrogenase 21
ATPase 19
xanthine phosphoribosyltransferase 17
glyceraldehyde-3-phosphate dehydrogenase 15
catalase 15
reverse transcriptase 15
glyceraldehyde-3-phosphate dehydrogenase 14
glyceraldehyde-3-phosphate dehydrogenase 14
glyceraldehyde-3-phosphate dehydrogenase 14
amidophosphoribosyltransferase 13
glutathione S-transferase 13
AMP deaminase 12
adenylosuccinate synthetase 12
DNA polymerase 12
superoxide dismutase 12
deaminase 10
orotate phosphoribosyltransferase 10
alpha-galactosidase 10
guanase 10
endonuclease 10
adenine deaminase 8
alkaline phosphatase 8
topoisomerase 8
topoisomerase 8
protein kinase 8
adenylate kinase 7
adenylosuccinate lyase 7
phosphorylase 7
RNA polymerase 7
tyrosine hydroxylase 6
deoxycytidine kinase 6
orotidine-5'-phosphate decarboxylase 6
aldehyde dehydrogenase 6
deoxyribonuclease 6
malate dehydrogenase 5
RNase 5
lactate dehydrogenase 5
xanthine dehydrogenase 5
peroxidase 5
trypsin 5
glutathione peroxidase 5
alanine aminotransferase 4
deoxyguanosine kinase 4
N-acetyltransferase 4
porphobilinogen deaminase 4
PRT 4
beta-galactosidase 4
thymidylate synthase 4
dihydrofolate reductase 4
glutathione reductase 4
GMP synthetase 4
focal adhesion kinase 4
monoamine oxidase 4
S1 nuclease 4
mitogen-activated protein kinase 4
renin 3
P-glycoprotein 3
beta-glucuronidase 3
methylthioadenosine phosphorylase 3
cytidine deaminase 3
galactokinase 3
NO synthase 3
DNA methyltransferase 3
uricase 3
pyruvate kinase 3
phenylalanine hydroxylase 3
RNase 3
more...
Compound
DNA 701
Dec 179
IMP 102
Clin 96
GMP 92
pyrene 60
pyrimidine 59
pyrimidine 59
phosphate 53
AMP 52
ATP 50
GTP 46
oxygen 40
sodium 37
Hypoxanthine 31
hydrogen 30
arginine 27
Purine 26
EMS 26
acetate 26
water 25
His 20
iron 19
methyl methanesulfonate 18
lysine 18
calcium 17
nitrogen 17
DMSO 15
sulfate 15
uridine 15
NAD 14
leucine 14
dGTP 14
creatinine 14
Guo 14
pyridine 14
tryptophan 13
PPi 13
Asp 13
NAD 13
anthracene 13
glucose 13
methionine 13
threonine 12
tyrosine 12
Phe 12
alanine 12
ADP 12
adenylate 12
ADP 12
ADP 12
HPP 12
valine 11
retinoic acid 11
1,3-Butadiene 11
PRPP 11
UTP 11
Adenine 10
aspartic acid 10
glutamate 10
serine 10
aspartic acid 10
Adenosine 10
aspartic acid 10
6-Thioguanine 10
glutamine 10
aspartic acid 10
Xanthine 10
DEAE 10
NADP 9
benzene 9
Ile 9
ethanol 9
Inosine 9
caffeine 9
cysteine 9
GSH 9
Adenine 9
GSH 9
methane 8
more...