Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P00492 (
hypoxanthine-guanine phosphoribosyltransferase
)
2,385
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
hypoxanthine-guanine phosphoribosyltransferase
2385
Mol
292
HPRT
253
Sep
189
AMP
158
X-linked
134
IMP
100
GMP
69
purine nucleoside phosphorylase
68
thymidine kinase
59
ATP
50
adenosine deaminase
50
GTP
44
fused
40
glucose-6-phosphate dehydrogenase
40
phosphoglycerate kinase
40
X-chromosome
39
adenosine kinase
37
xanthine oxidase
35
HAT
34
more...
Disease
Lesch-Nyhan syndrome
636
cancer
226
carcinogenesis
116
tumor
95
hyperuricemia
93
gout
72
mental retardation
51
mental retardation
51
self-injurious behavior
43
lymphoma
40
leukemia
39
choreoathetosis
29
arthritis
28
enzyme deficiency
25
carcinoma
21
renal failure
20
xeroderma pigmentosum
18
neuroblastoma
18
nephrolithiasis
17
anemia
17
more...
Symptom
spasticity
30
dystonia
18
pain
7
starvation
7
athetosis
6
vomiting
6
seizures
4
chorea
4
anesthesia
3
hypotonia
3
tremor
3
hypertonia
2
ataxia
2
abdominal pain
2
renal colic
2
dysarthria
2
weakness
2
clumsiness
2
hyperoxia
1
myoclonus
1
more...
Drug
Mutagen
81
G418
16
BH4
13
lysine
10
Adenosine deaminase
9
caffeine
9
DNase I
7
Adriamycin
6
IFN-gamma
6
CSF
4
AZT
4
AZT
4
Acyclovir
3
Etoposide
3
Dermatol
3
Thioguanine
3
ACT
3
-deoxyadenosine
3
Nephron
3
THF
3
more...
Enzyme
hypoxanthine-guanine phosphoribosyltransferase
1475
adenine phosphoribosyltransferase
132
purine nucleoside phosphorylase
67
thymidine kinase
59
adenosine deaminase
52
adenosine deaminase
50
phosphoglycerate kinase
43
glucose-6-phosphate dehydrogenase
43
xanthine oxidase
34
adenosine kinase
32
IMP dehydrogenase
25
5'-nucleotidase
24
glyceraldehyde-3-phosphate dehydrogenase
21
PRPP synthetase
21
ATPase
19
xanthine phosphoribosyltransferase
17
glyceraldehyde-3-phosphate dehydrogenase
15
catalase
15
reverse transcriptase
15
glyceraldehyde-3-phosphate dehydrogenase
14
more...
Compound
DNA
701
Dec
179
IMP
102
Clin
96
GMP
92
pyrene
60
pyrimidine
59
pyrimidine
59
phosphate
53
AMP
52
ATP
50
GTP
46
oxygen
40
sodium
37
Hypoxanthine
31
hydrogen
30
arginine
27
Purine
26
EMS
26
acetate
26
more...