Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P00492 (hypoxanthine-guanine phosphoribosyltransferase)
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Human Gene/Protein
WEE1 homolog 13.7
hypoxanthine-guanine phosphoribosyltransferase 13.7
60S ribosomal protein L13 13.7
TOP2 beta 12.4
60S ribosomal protein L32 12.1
MAE3 11.7
Neurexophilin 1 11.7
Calsyntenin-3 11.7
neurexophilin 3 11.7
Tp120 11.4
NPH2 11.4
PRTFDC1 11.4
engrailed homeobox 1 11.4
PPRibP 11.4
aprt 11.2
hypoxanthine guanine phosphoribosyltransferase 11.2
Mvp1 11.1
V3-3 11.1
neurexophilin 1 11.1
HPRT 11.0
40S ribosomal protein S12 10.9
ALDH16A1 10.9
RML2 10.7
60S acidic ribosomal protein P0 10.7
Adapter protein 10.5
succinate dehydrogenase complex subunit A 10.5
cadherin-9 10.5
Cysteine conjugate beta-lyase 10.4
Inosine 5'-monophosphate dehydrogenase 10.1
adenylosuccinate synthase 10.1
PSA2 10.0
selenium binding protein 1 10.0
GUK1 10.0
ribosomal protein L8 9.9
guanine deaminase 9.8
amidophosphoribosyltransferase 9.8
MDR/TAP 9.7
hypoxanthine phosphoribosyltransferase 1 9.6
C8G 9.5
VDAC-2 9.5
adenylosuccinate synthetase 9.5
GMP reductase 9.4
nicotinic acid phosphoribosyltransferase 9.3
LTV1 9.3
acyl-protein thioesterase 9.3
Guanine deaminase 9.3
LRRTM2 9.2
purine nucleoside phosphorylase 9.2
CDH10 9.2
THO2 9.1
Deoxyguanosine kinase 9.1
phosphoribosyl pyrophosphate amidotransferase 9.1
XMP 9.1
DRP2 9.1
BGR 9.0
UV20 9.0
SULT1C2 9.0
A-9 9.0
adenosine kinase 9.0
NPH4 8.9
ANXA11 8.9
70kD 8.8
3-hydroxyanthranilate 3,4-dioxygenase 8.8
adenylosuccinate lyase 8.8
IMP 8.8
SULT1B1 8.7
Sp5 8.7
dGK 8.7
THH 8.7
mannose phosphate isomerase 8.7
14-3-3 epsilon protein 8.7
mutS homolog 6 8.7
BTF2 8.7
ADORA2A 8.6
LAMR1 8.6
Beta-secretase 8.6
ribosomal protein L13a 8.6
deoxyguanosine kinase 8.6
peptidylprolyl isomerase A 8.5
ribosomal protein P0 8.5
CAD protein 8.5
HAT 8.5
nucleoside phosphorylase 8.5
betaine homocysteine methyltransferase 8.5
neuroligin 2 8.4
phosphoglycerate kinase 8.4
GMPS 8.4
Shwachman-Bodian-Diamond syndrome 8.4
Adenylosuccinate synthetase 8.4
OPRT 8.4
HPT1 8.3
tryptophan 5-monooxygenase 8.3
IMPDH1 8.3
ribosomal protein L19 8.3
MGR 8.3
AGAT 8.3
MYH1 8.2
GFRP 8.2
phenylalanine 4-monooxygenase 8.2
CD3E 8.2
hydroxymethylbilane synthase 8.1
GMP synthase 8.1
nuclear autoantigen 8.1
PRPS1 8.1
MAP kinase kinase 1 8.0
5'-methylthioadenosine phosphorylase 8.0
CD8B 8.0
AHH 8.0
GP120 8.0
APT1 8.0
ribosomal protein S5 8.0
UPIa 8.0
neurexin 1 8.0
methylthioadenosine phosphorylase 7.9
HsRad51 7.9
Beta-actin 7.9
GST T1 7.9
GART 7.8
WNT7B 7.8
IMPDH 7.8
CBR3 7.8
12E7 7.8
ADSL 7.8
MIC1 7.8
proteasome subunit alpha 7.8
SP5 7.8
adenosine monophosphate deaminase 7.7
X-linked recessive 7.7
STY 7.7
AMP deaminase 7.7
antiquitin 7.7
hPMS2 7.7
pyrimidine 5'-nucleotidase 7.7
RPL13A 7.6
SULT1A2 7.6
IMPDH2 7.6
GMP 7.6
neuroligin 1 7.6
Growth hormone receptor 7.6
dTMP kinase 7.6
DNA directed 7.6
beta-polymerase 7.6
hMSH3 7.6
ADORA2B 7.6
purH 7.5
DRD5 7.5
ADK 7.5
QR1 7.5
EN1 7.5
TGR 7.4
MCL 7.4
UBB 7.4
CTP synthetase 7.4
ATIC 7.4
MINT2 7.4
PSP94 7.4
SR-1 7.4
telokin 7.3
ubiquitin C 7.3
HOXB4 7.3
more...
Disease
Hyperuricemic nephropathy 13.7
Disorders of purine and pyrimidine metabolism 13.7
Deficiency of uracil phosphoribosyltransferase 13.7
Lesch-Nyhan syndrome 13.3
Kelley-Seegmiller syndrome 13.1
UMP synthase deficiency 12.1
purine metabolism disorder 10.9
Marie's ataxia 10.1
glycinuria 9.7
APRT deficiency 9.7
gouty nephropathy 9.6
PNP deficiency 9.5
choreoathetosis 9.4
self-injurious behavior 9.2
uricosuria 8.4
adult soft tissue sarcoma 8.4
hyperuricemia 8.4
articulation disorder 8.2
self-destructive behavior 8.0
enzyme deficiency 7.9
cystathioninuria 7.9
nervous disorder 7.8
ADA deficiency 7.6
gout 7.5
disorders of amino acid metabolism 7.4
MCL 7.4
neurobehavioral problems 7.3
18q- syndrome 7.1
tophi 7.1
AT3 7.1
AT3 7.1
AT3 7.1
AT3 7.1
AT3 7.1
AT3 7.1
AT3 7.1
AT3 7.1
AT3 7.1
orotic aciduria 6.8
DRD 6.8
familial disorder 6.6
sponge kidney 6.6
Fukuyama congenital muscular dystrophy 6.5
mouse leukemia L1210 6.5
nephrolithiasis 6.4
STY 6.4
xeroderma pigmentosum 6.4
hyperargininemia 6.3
dyserythropoietic anemia 6.2
Papillomas 6.1
hypobetalipoproteinemia 6.1
Bradley 6.0
secondary AML 6.0
XX males 6.0
XPD 6.0
abnormal involuntary movements 6.0
congenital hemolytic anemia 6.0
CPL 5.9
Tay-Sachs disease 5.9
chronic myeloproliferative disorders 5.8
CAE 5.8
megaloblastic anemia 5.7
CAE 5.7
nephrocalcinosis 5.5
Cockayne syndrome 5.5
spastic diplegia 5.5
mental retardation 5.4
mental retardation 5.4
thyroid neoplasm 5.4
MNS 5.4
XPB 5.3
dissociative disorder 5.3
malignant state 5.3
CEM 5.3
Severe sepsis 5.2
CREST 5.2
Lowe syndrome 5.2
SD1 5.2
trichothiodystrophy 5.2
harlequin 5.2
relapsing fever 5.1
mantle cell lymphoma 5.1
Sezary syndrome 5.0
RP1 5.0
folate deficiency 5.0
KMS 5.0
embryonal carcinoma 5.0
RBS 5.0
learning problem 4.9
familial dysautonomia 4.9
glycogen storage disease 4.9
fragile X syndrome 4.9
anosognosia 4.9
hepatic veno-occlusive disease 4.9
CSE 4.9
chemical carcinogenesis 4.9
homocystinuria 4.8
Schistosoma mansoni 4.8
maple syrup urine disease 4.8
induced psychosis 4.8
acute promyelocytic leukemia 4.8
Sandhoff disease 4.8
KMS 4.7
paroxysmal nocturnal hemoglobinuria 4.7
profound mental retardation 4.6
plasma cell leukemia 4.6
XPF 4.6
Fanconi syndrome 4.6
HPP 4.6
carcinogenesis 4.6
urolithiasis 4.6
amelanotic melanoma 4.6
Fanconi 4.5
compulsion 4.5
macrocytic anemia 4.5
HPP 4.5
tracheomalacia 4.5
hyperphenylalaninemia 4.5
cystinuria 4.4
STS 4.4
blast crisis 4.4
GCT 4.4
Farber 4.4
Tourette syndrome 4.4
phenylketonuria 4.4
moderate mental retardation 4.4
primary hyperoxaluria 4.3
Hurler 4.3
hemophilia B 4.3
kernicterus 4.3
methylmalonic acidemia 4.3
AIC 4.3
genetic disorder 4.3
Schwannoma 4.2
Schwannoma 4.2
severe mental retardation 4.2
acute nonlymphocytic leukemia 4.2
cerebral palsy 4.2
Leigh syndrome 4.2
chronic stable angina 4.1
RTS 4.1
neuroma 4.1
TMD 4.1
dysplastic nevi 4.0
galactosemia 4.0
emotional instability 4.0
neoplastic transformation 4.0
TCC 4.0
PND 4.0
developmental disabilities 4.0
trisomy 13 4.0
attention deficit disorder 4.0
CNS diseases 4.0
giardiasis 4.0
histiocytic lymphoma 3.9
brain disorder 3.9
testicular atrophy 3.9
second cancer 3.9
neurological disease 3.9
skin tumor 3.8
more...
Symptom
athetosis 8.3
chromosome marker 6.6
labored breathing 6.0
spasticity 6.0
clumsiness 5.6
renal colic 5.0
dystonia 4.8
chorea 4.7
Decreased activity 4.6
Fluctuation 4.5
hypertonia 4.4
forgetfulness 4.3
dysesthesia 3.8
muscle stiffness 3.4
dysarthria 2.8
hypotonia 2.8
flank pain 2.6
stridor 2.5
dysuria 2.4
HSA 2.2
colic 2.1
starvation 1.9
myoclonus 1.6
acute stress 1.5
hyperoxia 1.4
vomiting 1.3
lethargy 1.2
hepatomegaly 1.2
paresis 1.2
hemoptysis 1.1
tremor 1.1
ataxia 0.7
splenomegaly 0.4
sleepiness 0.1
abdominal pain -0.2
weakness -0.5
respiratory distress -0.6
seizures -0.6
nausea -0.8
overweight -1.0
dyspnea -1.1
analgesia -1.1
collapse -1.1
anesthesia -1.5
pain -1.5
fatigue -2.0
diarrhea -2.1
Drug
6-Methylpurine 10.4
Thioguanine 10.2
2-Methoxyethanol 9.1
8-Azaguanine 9.0
Adozelesin 8.9
Formycin B 8.5
Mercaptopurine 8.3
Neocarzinostatin 7.9
Mutagen 7.5
Adenosine deaminase 7.5
TMX 7.4
Rasburicase 7.3
BH4 6.8
Deoxyadenosine 6.8
Rasburicase 6.7
G418 6.6
Febuxostat 6.5
Adderall 6.4
Cytidine 5.8
Propidium 5.7
Cellulose acetate 5.6
KCL 5.6
Mycophenolic acid 5.3
Acyclovir 5.3
Etoposide 5.1
AGG 5.1
ddI 4.9
OMP 4.8
AIC 4.7
CFT 4.5
Helium 4.5
AZT 4.3
-deoxyadenosine 4.3
ACT 4.2
AZT 4.1
Adriamycin 4.1
Reserpine 3.7
Prednisone 3.7
CTC 3.7
AraC 3.7
Hypaque 3.6
Infliximab 3.6
Infliximab 3.6
DNase I 3.5
TAT 3.5
Hypaque 3.4
Arsenic trioxide 3.4
CTC 3.4
BLM 3.3
Meth 3.3
IFN-beta 3.1
Sorafenib 3.1
MIL 3.1
Parkin 2.8
Parkin 2.8
caffeine 2.5
Ouabain 2.4
Nitric Oxide 2.4
ETS 2.3
ICI 2.3
THF 2.3
Alanine 2.3
Vitamin E 2.0
Kenyan 1.9
p75 1.8
Asn 1.8
Spectrum 1.7
nitroglycerin 1.6
IFN-gamma 1.5
Ethanol 1.4
Glutathione 1.3
FAD 1.3
lysine 1.2
Bifidobacterium 1.2
Nephron 1.2
CaCl2 1.1
CaCl2 1.1
CaCl2 1.0
NH3 0.9
Gel 0.8
CSF 0.8
Spectrum 0.8
vitamin E 0.6
ABC 0.6
NADH 0.3
ascorbate 0.2
Nephron 0.1
IL-2 -0.1
ampicillin -0.3
ROS -0.5
Dial -1.2
Dermatol -2.7
Enzyme
hypoxanthine-guanine phosphoribosyltransferase 12.9
xanthine phosphoribosyltransferase 11.6
formyltetrahydrofolate deformylase 11.4
adenine phosphoribosyltransferase 11.3
amidophosphoribosyltransferase 10.5
PRPP synthetase 10.2
adenine deaminase 10.0
acyl-CoA:malonyl-CoA C-acyltransferase 10.0
3-methyladenine DNA glycosylase I 9.6
adenylosuccinate synthetase 9.6
purine nucleoside phosphorylase 9.3
deoxyadenosine kinase 9.3
guanase 9.2
EC 1.3.2.3 9.1
nicotinic acid phosphoribosyltransferase 9.1
adenylosuccinate lyase 9.0
GMP reductase 8.9
AICAR transformylase 8.9
adenosine kinase 8.8
orotate phosphoribosyltransferase 8.6
deoxyguanosine kinase 8.5
IMP dehydrogenase 8.5
GMP synthetase 8.5
IMP cyclohydrolase 8.4
DHOdehase 8.3
phosphoglycerate kinase 8.0
GMP synthase 7.9
orotidine-5'-phosphate decarboxylase 7.9
PRT 7.9
AMP deaminase 7.9
nucleoside phosphotransferase 7.8
3-hydroxyanthranilic acid oxygenase 7.7
glycinamide ribonucleotide transformylase 7.5
methylthioadenosine phosphorylase 7.4
CMP kinase 7.4
deoxycytidine deaminase 7.3
adenosine deaminase 7.1
adenosine deaminase 7.0
deoxycytidine kinase 6.8
nicotinamide mononucleotide adenylyltransferase 6.7
thymidine kinase 6.7
tripeptidase 6.7
5'-nucleotidase 6.7
S-adenosyl-L-homocysteine hydrolase 6.6
thymidylate kinase 6.5
endonuclease V 6.5
uridine phosphorylase 6.4
porphobilinogen deaminase 6.4
nucleoside diphosphokinase 6.4
NMT 6.3
3'-phosphatase 6.3
alpha-galactosidase 6.3
phosphomannose isomerase 6.2
glucose-6-phosphate dehydrogenase 6.2
guanylate kinase 6.2
thiopurine methyltransferase 6.2
EC 1.1.1.40 6.0
uracil phosphoribosyltransferase 6.0
galactokinase 6.0
uridine kinase 6.0
cyclohydrolase 5.9
deoxyribonuclease 5.8
xanthine oxidase 5.8
pantothenate kinase 5.8
xanthine dehydrogenase 5.8
AGT 5.7
CPL 5.7
ADH3 5.7
glyceraldehyde-3-phosphate dehydrogenase 5.6
alanine dehydrogenase 5.6
SpeB 5.6
dihydropyrimidinase 5.6
adenylate kinase 5.6
dihydroorotase 5.5
glyceraldehyde-3-phosphate dehydrogenase 5.4
glyceraldehyde-3-phosphate dehydrogenase 5.4
glyceraldehyde-3-phosphate dehydrogenase 5.4
alanine racemase 5.4
phosphoglycerate dehydrogenase 5.4
tryptophanyl-tRNA synthetase 5.4
cytidine deaminase 5.4
GTP cyclohydrolase I 5.3
Fpg protein 5.3
propionyl-CoA carboxylase 5.3
nucleotidase 5.3
propionyl-CoA carboxylase 5.3
DOPA decarboxylase 5.3
anthranilate synthase 5.2
nicotinamide phosphoribosyltransferase 5.2
aspartokinase 5.1
uricase 5.1
CGT 4.9
glyceraldehyde-3-phosphate dehydrogenase 4.8
phenylalanine hydroxylase 4.8
N-acetylglucosaminyltransferase 4.7
deaminase 4.7
TGT 4.7
carbonyl reductase 4.7
N-acetyltransferase 4.5
serine hydroxymethyltransferase 4.5
MTD 4.5
arylsulfatase 4.5
dihydropyrimidine dehydrogenase 4.4
methionine adenosyltransferase 4.3
type III procollagen 4.3
GCA 4.3
6-phosphogluconate dehydrogenase 4.2
polynucleotide phosphorylase 4.2
6-phosphogluconate dehydrogenase 4.2
glutamate synthase 4.1
peptidyl-prolyl cis-trans isomerase 4.1
microsomal epoxide hydrolase 4.1
phosphorylase 4.1
dihydropyrimidine dehydrogenase 4.0
aryl hydrocarbon hydroxylase 4.0
phosphoglucose isomerase 4.0
aspartate transcarbamylase 4.0
tryptophan hydroxylase 3.9
S-adenosylmethionine decarboxylase 3.9
ALDH 3.9
thymidylate synthase 3.9
S1 nuclease 3.9
malate dehydrogenase 3.9
ribonucleotide reductase 3.8
isocitrate lyase 3.8
ribonucleotide reductase 3.7
PTPase 3.7
glucose dehydrogenase 3.7
thymidine phosphorylase 3.7
aldehyde dehydrogenase 3.6
soluble epoxide hydrolase 3.6
topoisomerase 3.5
TAT 3.5
topoisomerase 3.4
CPS 3.4
TPP 3.4
transketolase 3.4
phosphoglucomutase 3.3
LPL 3.3
dopamine beta-hydroxylase 3.3
PGM 3.2
micrococcal nuclease 3.2
DNA polymerase 3.2
TPP 3.2
dihydrofolate reductase 3.2
transpeptidase 3.2
PAH 3.2
deoxyribonuclease 3.1
DNA methyltransferase 3.0
chloramphenicol acetyltransferase 3.0
ornithine transcarbamylase 3.0
isocitrate dehydrogenase 3.0
glutathione S-transferase 2.9
pyruvate kinase 2.9
glycerol-3-phosphate dehydrogenase 2.9
glycerol-3-phosphate dehydrogenase 2.9
prostaglandin synthetase 2.9
endonuclease 2.8
TdT 2.8
PRE 2.8
more...
Compound
1-(3-pyridinyl)-2-butanone 13.7
6-Ethylmercaptopurine 13.7
C10H12N4O5S 12.7
Marmesin 11.7
C7H8N4S 11.7
Disperse Red 11 11.4
methoxyacetaldehyde 11.3
R 48 11.1
Marmesin 10.9
6-Mercaptopurine riboside 10.9
R 7000 10.7
1,8-Dinitropyrene 10.4
6-Methylpurine 10.4
Inosinic acid 10.4
Ammonium metavanadate 10.1
6-Methylpurine 10.1
Hypoxanthine 10.1
6-Thioguanine 10.0
Myosmine 9.8
N-Hydroxy-2-acetylaminofluorene 9.7
Orotidine 9.6
Prunetin 9.5
Cryptolepine 9.5
1,3-Butadiene 9.4
1,6-Dinitropyrene 9.4
PRPP 9.4
Tiazofurin 9.4
1,2-butanediol 9.3
XMP 9.2
ENNG 9.0
Aminoimidazole 8.9
1H-phenalen-1-one 8.8
IMP 8.7
Metanephrine 8.7
Lead nitrate 8.6
Bathocuproine 8.6
Xanthine 8.5
Formycin B 8.5
Formycin B 8.5
Purine 8.5
WR-1065 8.4
Glycidol 8.4
N-ethylurea 8.3
CI-921 8.3
dGDP 8.3
Normetanephrine 8.2
7H-dibenzo[c,g]carbazole 8.2
Diepoxybutane 8.1
isopropyl acetate 8.0
Neocarzinostatin 8.0
HNS 7.9
6-Mercaptopurine 7.9
Inosine 7.8
Kojic acid 7.8
Potassium bromate 7.7
2-ethylhexyl acrylate 7.7
5H-pyrido[4,3-b]indole 7.6
4-NQO 7.5
Phenolphthalein 7.5
Phenolphthalein 7.4
3-methoxybenzamide 7.4
XTP 7.4
Myrcene 7.3
Deoxyguanosine 7.3
TGR 7.3
methoxyacetic acid 7.3
Guanidinoacetic acid 7.2
Trifluorothymidine 7.2
1-methylhistidine 7.2
MMU 7.2
2-methoxyethanol 7.1
Propoxur 7.1
PhIP 7.1
dGTP 7.1
GMP 7.1
NaAsO2 7.1
O6-Methylguanine 7.1
5-methylchrysene 7.0
Scopoletin 7.0
2-OHE1 7.0
Chloroacetaldehyde 6.9
bromoacetic acid 6.9
ENU 6.9
Acivicin 6.9
3-aminobenzamide 6.8
9H-pyrido[2,3-b]indole 6.8
Deoxyadenosine 6.8
HPP 6.8
adenylosuccinate 6.8
Ellipticine 6.8
dibromomethane 6.7
Ethylene oxide 6.7
NOP 6.7
methyl methanesulfonate 6.6
ribose-5-phosphate 6.6
MNNG 6.5
triethyl phosphate 6.5
Vinyl chloride 6.5
Adenine 6.5
Trp-P-2 6.5
PPi 6.4
Palmitoleic acid 6.4
alpha-Naphthoflavone 6.4
alpha-Naphthoflavone 6.4
alpha-Naphthoflavone 6.4
Cyd 6.3
benzo[ghi]perylene 6.3
EMS 6.3
2-imidazolidinone 6.3
2(5H)-furanone 6.2
2-methoxyethyl 6.2
8-quinolinol 6.2
MNT 6.2
2-methoxyethyl 6.2
SC-1 6.1
SC-1 6.1
Domoic acid 6.0
Guanine 6.0
AICAR 6.0
MNU 5.9
CPL 5.9
Styrene 5.9
ethyl acrylate 5.9
methylphosphonic acid 5.8
methylphosphonic acid 5.8
methylphosphonic acid 5.8
Uric acid 5.8
MGBG 5.8
MGBG 5.8
chloroacetic acid 5.8
pentanal 5.7
Azan 5.7
4-Hydroxynonenal 5.7
pentanal 5.7
MNU 5.7
dGMP 5.6
benzo[a]anthracene 5.6
BSH 5.6
Tocopherols 5.6
Diol 5.6
UMP 5.6
4-hydroxybenzaldehyde 5.6
4-hydroxybenzaldehyde 5.6
4-hydroxybenzaldehyde 5.5
4-hydroxybenzaldehyde 5.5
NMN 5.5
Chlorambucil 5.5
dCTP 5.5
IDP 5.4
Adenine 5.4
Diacetyl 5.4
AAF 5.4
2,2,6,6-tetramethylpiperidine 5.4
Parks 5.4
pyrene 5.3
methyl acrylate 5.3
4-hydroxybenzaldehyde 5.3
HMF 5.3
pyrimidine 5.3
Acyclovir 5.3
more...