Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P00492 (hypoxanthine-guanine phosphoribosyltransferase)
 2,385 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
hypoxanthine-guanine phosphoribosyltransferase 2385
Mol 292
HPRT 253
Sep 189
AMP 158
X-linked 134
IMP 100
GMP 69
purine nucleoside phosphorylase 68
thymidine kinase 59
adenosine deaminase 50
ATP 50
GTP 44
glucose-6-phosphate dehydrogenase 40
fused 40
phosphoglycerate kinase 40
X-chromosome 39
adenosine kinase 37
xanthine oxidase 35
HAT 34
X-linked recessive 32
p53 31
housekeeping 29
hypoxanthine guanine phosphoribosyltransferase 29
hemoglobin 22
5'-nucleotidase 20
aprt 20
ATPase 18
lymphoid 15
glyceraldehyde-3-phosphate dehydrogenase 14
cytochrome P450 14
polypeptide 13
NAD 13
beta-actin 13
catalase 13
Gen 13
promyelocytic leukemia 12
erythroid 12
amidophosphoribosyltransferase 12
ADP 12
T cell receptor 11
microsomal 11
glycophorin A 11
cytokine 11
superoxide dismutase 11
endonuclease 10
glutathione S-transferase 10
thymus 10
adenylosuccinate synthetase 10
c-myc 9
alpha-galactosidase 9
guanine deaminase 9
insulin 9
threonine 9
MCL 9
Adenosine deaminase 9
AMP deaminase 8
GSH 8
oxidoreductase 8
alkaline phosphatase 8
DNA polymerase 8
telomeric 8
beta-globin 7
GDP 7
H2AX 7
transferrin receptor 7
CYP1A1 7
methylguanine-DNA methyltransferase 7
DNase I 7
ras 7
cryptic 7
XMP 7
tyrosine hydroxylase 7
AHH 7
anonymous 7
Met 7
adenylate kinase 7
CYP1A2 6
interferon 6
epidermal growth factor 6
G6PD 6
ADA 6
HLA 6
NMR 6
nucleoside phosphorylase 6
XPD 6
adenylosuccinate lyase 6
IFN-gamma 6
cytochrome 6
deoxycytidine kinase 6
tRNA 6
glyceraldehyde 3-phosphate dehydrogenase 6
alternatively spliced 6
NADP 6
amyloid precursor protein 5
pseudogene 5
ACTB 5
pol 5
hMLH1 5
glycoprotein 5
CD4 5
Inosine 5'-monophosphate dehydrogenase 5
O6-methylguanine-DNA methyltransferase 5
granulocyte 5
Bcl-2 5
IL-8 5
CTP 5
interleukin-2 5
cell surface antigen 5
colon carcinoma 5
She 5
P450 5
SDS 5
GST 5
SCH 5
GSTM1 5
membrane-bound 5
growth hormone 4
poly(ADP-ribose) polymerase 4
SOD 4
NADPH 4
Rad51 4
TGR 4
RAD51 4
nerve growth factor 4
olfactory 4
dihydrofolate reductase 4
glutathione peroxidase 4
N-acetyltransferase 4
Polymerase 4
proto-oncogene 4
UTR 4
IL-10 4
beta-2-microglobulin 4
1A1 4
albumin 4
collagen 4
xenobiotic 4
PGK 4
malate dehydrogenase 4
NAT2 4
hole 4
interleukin 2 4
p160 4
deoxyguanosine kinase 4
IMPDH 4
xanthine dehydrogenase 4
hMSH2 4
heavy chain 4
LPS 4
GSTT1 4
PNP 4
GPT 4
XRCC1 4
sex hormone-binding globulin 4
catechol-O-methyltransferase 4
nitric oxide synthase 4
mer 4
MSV 4
DNA methyltransferase 3
more...
Disease
Lesch-Nyhan syndrome 636
cancer 226
carcinogenesis 116
tumor 95
hyperuricemia 93
gout 72
mental retardation 51
mental retardation 51
self-injurious behavior 43
lymphoma 40
leukemia 39
choreoathetosis 29
arthritis 28
enzyme deficiency 25
carcinoma 21
renal failure 20
neuroblastoma 18
xeroderma pigmentosum 18
nephrolithiasis 17
anemia 17
acute promyelocytic leukemia 16
Schistosoma mansoni 15
acute lymphoblastic leukemia 15
immunodeficiency 15
hepatocellular carcinoma 15
renal disease 14
genetic disorder 13
cerebral palsy 13
autism 13
herpes simplex 13
CEM 12
breast cancer 11
neurological disease 10
Epstein 10
Down syndrome 9
MCL 9
malaria 9
mantle cell lymphoma 9
tumorigenesis 9
GSH 8
chronic myeloid leukemia 8
Alzheimer's disease 8
acute renal failure 8
fragile X syndrome 8
embryonal carcinoma 8
fits 8
developmental delay 8
ATM 8
tuberculosis 7
fibrosarcoma 7
lung cancer 7
diabetes 7
acute myeloid leukemia 7
adenocarcinoma 7
malnutrition 7
infectious diseases 7
Tay-Sachs disease 7
urolithiasis 7
Hodgkin's disease 7
Fanconi 7
depression 7
Chagas 7
developmental disabilities 6
Mycobacterium 6
MCF 6
schizophrenia 6
Huntington's disease 6
neoplastic transformation 6
Kelley-Seegmiller syndrome 6
Parkinson's disease 6
hypertension 6
melanoma 6
inflammatory bowel disease 6
ADA deficiency 6
aggression 6
skin cancer 6
Duchenne muscular dystrophy 5
phenylketonuria 5
myelodysplastic syndrome 5
nephrocalcinosis 5
multiple sclerosis 5
tophi 5
renal insufficiency 5
SCH 5
megaloblastic anemia 5
Tourette syndrome 5
APRT deficiency 5
lung carcinoma 5
cognitive impairment 5
SDS 5
XPD 4
self-destructive behavior 4
West 4
cold 4
folate deficiency 4
renal impairment 4
Cockayne syndrome 4
STS 4
erythroleukemia 4
PNP deficiency 4
chronic lymphocytic leukemia 4
multiple myeloma 4
childhood cancer 4
Leukemia 4
schistosomiasis 4
tumor progression 4
cystic fibrosis 4
metabolic disorder 4
Infection 4
HIV 4
blast crisis 4
uremia 4
squamous cell carcinoma 4
colon cancer 4
BLM 3
parkinsonism 3
colorectal cancer 3
SCID 3
chronic lymphocytic leukemia 3
tumor growth 3
leukemogenesis 3
Blocking 3
non-Hodgkin's lymphoma 3
pheochromocytoma 3
myeloproliferative disorders 3
Mycoplasma 3
hypothyroidism 3
Chlamydia 3
secondary AML 3
worms 3
stroke 3
uricosuria 3
abnormal involuntary movements 3
idiopathic thrombocytopenic purpura 3
APC 3
CNS diseases 3
AIDS 3
virus infection 3
glycogen storage disease 3
acute leukemia 3
ABL 3
Bradley 3
haemophilia 3
chemical carcinogenesis 3
coronary artery disease 3
mammary tumor 3
rheumatoid arthritis 3
renal cell carcinoma 3
pneumonia 3
Fanconi syndrome 3
wasting 3
uterus 3
paroxysmal nocturnal hemoglobinuria 3
suicide 3
African trypanosomiasis 3
DBA 3
AT3 2
thalassemia 2
AT3 2
confusion 2
more...
Symptom
spasticity 30
dystonia 18
starvation 7
pain 7
athetosis 6
vomiting 6
chorea 4
seizures 4
anesthesia 3
tremor 3
hypotonia 3
hypertonia 2
dysarthria 2
abdominal pain 2
renal colic 2
weakness 2
clumsiness 2
ataxia 2
dyspnea 1
overweight 1
labored breathing 1
dysesthesia 1
hepatomegaly 1
dysuria 1
forgetfulness 1
muscle stiffness 1
lethargy 1
hyperoxia 1
acute stress 1
fatigue 1
splenomegaly 1
analgesia 1
myoclonus 1
hemoptysis 1
diarrhea 1
colic 1
HSA 1
chromosome marker 1
paresis 1
nausea 1
Decreased activity 1
sleepiness 1
collapse 1
flank pain 1
respiratory distress 1
stridor 1
Fluctuation 1
Drug
Mutagen 81
G418 16
BH4 13
lysine 10
Adenosine deaminase 9
caffeine 9
DNase I 7
IFN-gamma 6
Adriamycin 6
CSF 4
AZT 4
AZT 4
Thioguanine 3
Acyclovir 3
Nephron 3
Etoposide 3
Asn 3
THF 3
-deoxyadenosine 3
ACT 3
Dermatol 3
ascorbate 2
ICI 2
Rasburicase 2
vitamin E 2
AGG 2
TAT 2
NADH 2
Neocarzinostatin 2
nitroglycerin 2
IFN-beta 2
IL-2 2
Ethanol 2
Gel 2
Adozelesin 1
Dial 1
Reserpine 1
CTC 1
ETS 1
Deoxyadenosine 1
Ouabain 1
ddI 1
Febuxostat 1
Infliximab 1
6-Methylpurine 1
CaCl2 1
Hypaque 1
Kenyan 1
Mercaptopurine 1
Mycophenolic acid 1
Adderall 1
ROS 1
Parkin 1
Cellulose acetate 1
Meth 1
Parkin 1
Prednisone 1
p75 1
TMX 1
FAD 1
Cytidine 1
Helium 1
CaCl2 1
ABC 1
Formycin B 1
AraC 1
BLM 1
CFT 1
Infliximab 1
AIC 1
Arsenic trioxide 1
ampicillin 1
Propidium 1
8-Azaguanine 1
CTC 1
MIL 1
CaCl2 1
Glutathione 1
KCL 1
Nitric Oxide 1
Hypaque 1
Bifidobacterium 1
Spectrum 1
Sorafenib 1
Spectrum 1
2-Methoxyethanol 1
OMP 1
Vitamin E 1
Nephron 1
Rasburicase 1
NH3 1
Alanine 1
Enzyme
hypoxanthine-guanine phosphoribosyltransferase 1475
adenine phosphoribosyltransferase 132
purine nucleoside phosphorylase 67
thymidine kinase 59
adenosine deaminase 52
adenosine deaminase 50
phosphoglycerate kinase 43
glucose-6-phosphate dehydrogenase 43
xanthine oxidase 34
adenosine kinase 32
IMP dehydrogenase 25
5'-nucleotidase 24
PRPP synthetase 21
glyceraldehyde-3-phosphate dehydrogenase 21
ATPase 19
xanthine phosphoribosyltransferase 17
reverse transcriptase 15
glyceraldehyde-3-phosphate dehydrogenase 15
catalase 15
glyceraldehyde-3-phosphate dehydrogenase 14
glyceraldehyde-3-phosphate dehydrogenase 14
glyceraldehyde-3-phosphate dehydrogenase 14
glutathione S-transferase 13
amidophosphoribosyltransferase 13
DNA polymerase 12
AMP deaminase 12
superoxide dismutase 12
adenylosuccinate synthetase 12
deaminase 10
guanase 10
endonuclease 10
alpha-galactosidase 10
orotate phosphoribosyltransferase 10
protein kinase 8
adenine deaminase 8
alkaline phosphatase 8
topoisomerase 8
topoisomerase 8
adenylate kinase 7
adenylosuccinate lyase 7
RNA polymerase 7
phosphorylase 7
aldehyde dehydrogenase 6
orotidine-5'-phosphate decarboxylase 6
deoxycytidine kinase 6
deoxyribonuclease 6
tyrosine hydroxylase 6
xanthine dehydrogenase 5
malate dehydrogenase 5
RNase 5
peroxidase 5
trypsin 5
glutathione peroxidase 5
lactate dehydrogenase 5
GMP synthetase 4
deoxyguanosine kinase 4
thymidylate synthase 4
S1 nuclease 4
glutathione reductase 4
alanine aminotransferase 4
N-acetyltransferase 4
focal adhesion kinase 4
monoamine oxidase 4
beta-galactosidase 4
dihydrofolate reductase 4
PRT 4
porphobilinogen deaminase 4
mitogen-activated protein kinase 4
P-glycoprotein 3
cytidine deaminase 3
galactokinase 3
NO synthase 3
DNA methyltransferase 3
acetylcholinesterase 3
RNase 3
APC 3
pyruvate kinase 3
ribonucleotide reductase 3
ribonucleotide reductase 3
DOPA decarboxylase 3
gamma-glutamyl transpeptidase 3
uricase 3
AGT 3
PAH 3
succinate dehydrogenase 3
beta-glucuronidase 3
renin 3
thiopurine methyltransferase 3
nucleotidase 3
ERK 3
phenylalanine hydroxylase 3
methylthioadenosine phosphorylase 3
nicotinic acid phosphoribosyltransferase 3
chloramphenicol acetyltransferase 3
CYP3A4 3
cyclohydrolase 2
AMP-activated protein kinase 2
uridine phosphorylase 2
cathepsin B 2
AICAR transformylase 2
MIP 2
transcriptase 2
glycinamide ribonucleotide transformylase 2
caspase-3 2
soluble epoxide hydrolase 2
S-adenosyl-L-homocysteine hydrolase 2
phosphomannose isomerase 2
CAD 2
phosphoglucose isomerase 2
DNase 2
carbonic anhydrase 2
GMP reductase 2
micrococcal nuclease 2
phosphodiesterase 2
deoxyadenosine kinase 2
choline acetyltransferase 2
isocitrate dehydrogenase 2
dihydropyrimidine dehydrogenase 2
TAT 2
GTP cyclohydrolase I 2
6-phosphogluconate dehydrogenase 2
tryptophan hydroxylase 2
tyrosinase 2
guanylate kinase 2
adenylate cyclase 2
AMPK 2
protein kinase C 2
thymidylate kinase 2
luciferase 2
aryl hydrocarbon hydroxylase 2
cholinesterase 2
arylsulfatase 2
6-phosphogluconate dehydrogenase 2
CAD 2
proteasome 2
CAD 2
anthranilate synthase 1
AMPK 1
glutamate synthase 1
GCA 1
pantothenate kinase 1
tryptophanyl-tRNA synthetase 1
TGT 1
proteinase K 1
PARP 1
NMT 1
TdT 1
3'-phosphatase 1
alpha-amylase 1
glycerol-3-phosphate dehydrogenase 1
formyltetrahydrofolate deformylase 1
serine hydroxymethyltransferase 1
thymidine phosphorylase 1
tissue plasminogen activator 1
uracil phosphoribosyltransferase 1
MEK 1
acyl-CoA:malonyl-CoA C-acyltransferase 1
LPL 1
CPL 1
dihydropyrimidinase 1
more...
Compound
DNA 701
Dec 179
IMP 102
Clin 96
GMP 92
pyrene 60
pyrimidine 59
pyrimidine 59
phosphate 53
AMP 52
ATP 50
GTP 46
oxygen 40
sodium 37
Hypoxanthine 31
hydrogen 30
arginine 27
acetate 26
EMS 26
Purine 26
water 25
His 20
iron 19
methyl methanesulfonate 18
lysine 18
nitrogen 17
calcium 17
uridine 15
DMSO 15
sulfate 15
leucine 14
NAD 14
Guo 14
creatinine 14
dGTP 14
pyridine 14
PPi 13
anthracene 13
glucose 13
NAD 13
Asp 13
methionine 13
tryptophan 13
threonine 12
alanine 12
ADP 12
tyrosine 12
adenylate 12
HPP 12
ADP 12
Phe 12
ADP 12
valine 11
1,3-Butadiene 11
retinoic acid 11
UTP 11
PRPP 11
aspartic acid 10
glutamine 10
6-Thioguanine 10
glutamate 10
aspartic acid 10
DEAE 10
aspartic acid 10
serine 10
Adenosine 10
Xanthine 10
Adenine 10
aspartic acid 10
caffeine 9
cysteine 9
ethanol 9
Ile 9
GSH 9
benzene 9
GSH 9
Adenine 9
NADP 9
Inosine 9
zinc 8
chromium 8
3-aminobenzamide 8
tryptophan 8
tryptophan 8
tryptophan 8
methane 8
nitric oxide 8
PEG 8
bromide 8
aflatoxin B1 7
cAMP 7
cadmium 7
ENU 7
XMP 7
SDS 7
Mg2+ 7
urea 7
6-Mercaptopurine 7
GDP 7
gamma-aminobutyric acid 7
Guanine 7
H2O2 7
COS 7
glutamic acid 6
aldehyde 6
quinoline 6
Adriamycin 6
quinoline 6
Uric acid 6
Cardiol 5
acrylamide 5
hydroxyindoleacetic acid 5
isoleucine 5
dCTP 5
Gly 5
silver 5
isoleucine 5
galactose 5
nickel 5
Methotrexate 5
selenium 5
ammonium 5
potassium 5
CO2 5
Tiazofurin 5
WR-1065 5
TGR 5
MNNG 5
TTP 5
CTP 5
salt 5
proline 5
glucose-6-phosphate 5
Guo 5
nicotinic acid 4
PhIP 4
nicotinic acid 4
HNS 4
silicon 4
5-HT 4
GPT 4
nicotinic acid 4
AICAR 4
5-hydroxytryptophan 4
BLM 4
acridine 4
PNP 4
AICAR 4
nicotinic acid 4
methanol 4
AAF 4
ammonia 4
Cyt 4
dATP 4
phenanthrene 4
NADPH 4
iodine 4
VP-16 4
5H-pyrido[4,3-b]indole 4
asparagine 4
more...