Gene/Protein
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Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
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Query: UNIPROT:O76050 (
neu
)
3,969
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of aqueous extract of
Schizandra Chinensis Fruit
(AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl
2
(0.6 mg/kg/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (
5-HT
), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA,
5-HT
and 5-HIAA in Cd intoxicated rats (
P
< 0.05), while pretreatment with AESC (20 mg/kg/d or 60 mg/kg/d, p.o., 30 min before CdCl
2
) greatly inhibited the decrease of monoamine transmitters, respectively (
P
< 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by CdCl
2
. These results suggest that AESC ameliorates Cd-induced depletion of monoamine
neu
-rotransmitters in brain through its antioxidant activity.
...
PMID:Effects of Aqueous Extract of
Schizandra Chinensis Fruit
on Cadmium-Induced Change of Monoamine Neurotransmitters in Rats. 3203 14
