Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:O76050 (
neu
)
3,969
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
CBA, C3HA, C57Bl, Balb/c and DBA female mice received 20 subcutaneous weekly injections of 1,2-dimethylhydrazine in the dose of 8 mg/kg body weight. Estrous cycles were studied in vaginal smears taken 5, 10, 15 and 20 weeks after the 1st
DMH
injection. In CBA strain susceptible to
DMH
induction of uterine sarcomas a persistent estrus was observed in 50% of mice after 5 to 10
DMH
injections. In C3HA, C57B1, Balb/c and DBA strains resistant to the
DNH
induction of uterine sarcomas persistent estrus was not observed; the majority of these mice retained a normal estrus cycle. Persistent diestrus which was absent in susceptible CBA mice was found in these resistant strains. No CBA females with a normal estrous cycle were observed after the beginning of
DMH
treatment. The differences in the estrous cycle found in the mouse strains treated with
DMH
may partly explain the observed strain differences in the susceptibility to the
DMH
induction of uterine sarcomas.
...
PMID:[Effect of 1,2-dimethylhydrazine on the estrous cycle in different strains of mice]. 380 85
