Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:O75628 (REM)
 5,581 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
REM 12.5
calcium-signal modulating cyclophilin ligand 10.9
REMP 10.4
SWA 10.2
REM1 10.2
APSS 9.8
TRA@ 9.7
BNIP-Salpha 9.7
SWS 9.6
beta3 adrenoceptor 9.5
TMUB1 9.2
HSFA 9.2
dream 8.8
PSG 8.8
SWS2 8.8
hypocretin receptor 2 8.7
JUMONJI 8.5
DORA 8.4
HRH3 8.4
Ras-GRF2 8.3
CIRBP 8.0
RGL3 8.0
orexin 7.9
orexin receptor-1 7.8
ALTE 7.7
type III adenylyl cyclase 7.7
Kir2.4 7.7
DQw 7.6
hSyn 7.6
GRF2 7.6
adenylate cyclase 3 7.6
GEFH1 7.6
PLM 7.5
DQ1 7.4
steroid acute regulatory protein 7.3
MCH-R1 7.2
INOS 7.2
rat homolog 7.1
CPAP 7.1
OX1R 7.1
Orexin 7.1
MC7 7.0
OX2R 7.0
HDB 7.0
MBNL2 7.0
DST 6.9
LHA 6.9
m3 muscarinic receptor 6.9
PPT 6.9
Succinic semialdehyde dehydrogenase 6.8
TRN 6.8
TAAR1 6.8
SIDS 6.7
inhibitor-3 6.7
PLB1 6.7
RGL 6.6
rhodanese 6.6
RGL2 6.6
Cdc42GAP 6.6
BNIP-2 6.6
RDC 6.6
IL1RAPL1 6.4
PRKG1 6.4
EPAC2 6.4
OX2 6.4
LEC2 6.3
RalGDS 6.3
SWS1 6.3
FRA 6.3
attractin 6.2
calcium-modulating cyclophilin ligand 6.2
cocaine and amphetamine regulated transcript 6.2
theta-1 6.2
neuroligin 2 6.2
PPN 6.2
JME 6.2
melanin-concentrating hormone 6.1
GLRA1 6.1
XFS 6.1
DSP-4 6.1
more...
Disease
Sleep-related painful erections 11.7
Apneic attacks 11.2
Sleep attacks 10.6
REM sleep behavior disorder 10.5
SWS 10.5
Sleep talking 10.5
parasomnia 10.3
sleep terrors 10.3
APSS 10.2
Bonnet's syndrome 10.2
chronic chorea 9.9
moria 9.9
Narcolepsy with cataplexy 9.9
cataplexy 9.7
sleepwalking 9.5
Trisomy 17 9.5
Internal hydrocephalus 9.3
Recurrent apnea 9.3
narcolepsy 9.1
Pseudodementia 8.9
Recurrent depression 8.9
sleep epilepsy 8.9
Benign neonatal sleep myoclonus 8.9
infantile apnea 8.8
Periodic Limb Movement Disorder 8.7
SWS 8.6
behavior disorder 8.5
Vascular parkinsonism 8.5
Chronic paroxysmal hemicrania 8.5
Chronic insomnia 8.4
Kleine-Levin syndrome 8.3
Primary insomnia 8.1
Epileptic encephalopathy 8.1
sleep disorders 8.0
Mild depression 8.0
sleep disturbances 7.8
Morvan 7.8
Hypoprolactinemia 7.8
Epilepsia partialis continua 7.7
Minimally Conscious State 7.6
Obesity hypoventilation syndrome 7.5
sleep apnea 7.5
combat fatigue 7.4
Ondine's curse 7.3
Central sleep apnea 7.3
Ondine's curse 7.3
head-banging 7.2
Upper airway obstruction 7.2
restless legs syndrome 7.2
ring chromosome 20 7.2
Lennox syndrome 7.1
transcortical aphasia 7.1
obstructive sleep apnea 7.0
Sleep disturbance 6.9
bruxism 6.8
nocturnal leg cramps 6.8
brain anoxia 6.8
clinical depression 6.7
anxious state 6.6
Gerhardt 6.6
RDC 6.6
Multiple chemical sensitivity 6.5
Landau-Kleffner syndrome 6.5
Pineal gland 6.5
Pineal gland 6.5
Pineal gland 6.5
psychomotor epilepsy 6.5
vagotonia 6.4
FFI 6.4
Neurodegenerative Disorders 6.4
Pure autonomic failure 6.3
organic impotence 6.2
FRA 6.2
Economo 6.2
hallucinations 6.2
Dementia with Lewy bodies 6.1
psychogenic impotence 6.1
familial alcoholism 6.1
Temporal lobe 6.1
CHEST 6.0
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Symptom
Biot's breathing 10.9
hypnagogic hallucination 10.0
Hypersomnolence 9.4
hypersomnia 9.1
Periodic breathing 8.8
painful erections 8.3
Respiratory abnormalities 8.1
Lower abdominal pain 8.0
Rebound insomnia 8.0
sleepiness 7.5
eds 7.3
insomnia 7.3
snoring 7.2
hangover 7.1
abnormal breathing 7.1
visual hallucination 6.9
Poor sleep 6.8
situational stress 6.1
Motor dysfunction 6.1
Parkinsonian tremor 6.1
CSR 6.0
twitching 5.9
enuresis 5.9
sighing 5.9
bradypnea 5.8
myoclonus 5.7
nocturnal cough 5.7
partial seizure 5.6
auditory hallucination 5.5
hypercapnia 5.3
bedwetting 5.3
anosmia 5.2
motor symptom 5.2
Deafferentation 5.1
hypocapnia 5.1
hypalgesia 5.0
POA 5.0
tonic seizure 4.8
bradykinesia 4.7
hot flashes 4.4
excessive sweating 4.3
chorea 4.2
hypertonia 4.2
thirsty 4.1
Psychiatric symptoms 4.1
hypotonia 4.0
tachypnea 4.0
prostration 3.9
eye pain 3.9
stridor 3.9
dystonia 3.8
seizures 3.5
lightheadedness 3.5
muscle rigidity 3.4
ataxic gait 3.4
catatonia 3.4
nasal congestion 3.3
agitation 3.3
mental fatigue 3.3
decreased appetite 3.3
Fluctuation 3.2
tremor 3.2
tonic-clonic seizure 3.1
Depressive symptoms 3.1
Sedation 3.1
constipation 3.1
cerebellar ataxia 3.0
dysarthria 2.9
despair 2.8
apathy 2.8
memory loss 2.7
fatigue 2.7
lethargy 2.6
ataxia 2.5
blepharospasm 2.5
abnormal gait 2.3
hot flushes 2.2
cyanosis 2.2
fasciculation 2.1
hyperoxia 2.1
more...
Drug
Safrazine hydrochloride 12.5
Eptapirone 12.5
Fosazepam 12.5
Repetin 9.3
Doxepine 9.2
Trimipramine 9.0
Mecobalamin 8.8
Brotizolam 8.8
Requip 8.7
Flurazepam 8.7
Dexmedetomidine hydrochloride 8.2
Ambien 8.2
Requip 8.2
Mifepriston 8.2
Bretazenil 8.0
Lormetazepam 7.9
Remeron 7.9
Etizolam 7.9
Alaproclate 7.6
Dormicum 7.4
LAAM 7.4
Abecarnil 7.3
LCBF 7.3
Zonisamide 7.2
Eszopiclone 7.0
Flunitrazepam 6.8
Nabilone 6.8
Triazolam 6.7
Nisoxetine 6.7
Cilazapril 6.4
Enprofylline 6.2
Peppermint 6.2
Modafinil 6.2
Zyban 6.1
Deuterium oxide 6.0
Agomelatine 6.0
Pramipexole 5.8
Gallamine 5.8
Pramipexole 5.7
Mazindol 5.6
Flupenthixol 5.6
Spiegel 5.6
Sinemet 5.6
Lasalocid 5.5
Acamprosate 5.2
Mirtazapine 5.2
Tianeptine 5.2
Monosodium glutamate 5.1
Beta-2 5.1
Ritanserin 5.0
Moclobemide 5.0
Apomorphine 4.8
Diurnal 4.5
RAL 4.5
Pitressin 4.4
Donepezil 4.4
Frontal 4.3
Sulpiride 4.3
IPD 4.3
Duloxetine 4.2
CPZ 4.2
Sodium valproate 4.2
Theophylline 4.1
Cisapride 4.1
Clonidine 4.1
Phentolamine 3.9
all-trans-retinol 3.8
9-THC 3.7
Scopolamine 3.7
Pregabalin 3.7
DBS 3.7
MDS 3.7
DEX 3.6
GRF 3.5
Singular 3.5
DMI 3.4
DHT 3.4
DHT 3.3
Triad 3.2
CFS 3.2
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Enzyme
LDT 9.7
GBH 7.2
SPT 6.0
FFT 5.9
DSR 5.6
SPT 5.2
Alternating 5.0
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.8
phosphatidate phosphatase 4.8
pantothenate kinase 4.5
C3b inactivator 4.5
DAT 4.3
dopamine beta-hydroxylase 4.0
monoamine oxidase 3.8
DMT 3.6
choline acetyltransferase 3.6
histidine decarboxylase 3.5
aldehyde reductase 3.5
aldehyde reductase 3.5
aldehyde reductase 3.4
5alpha-reductase 3.4
5alpha-reductase 3.4
cytochrome P-450scc 3.3
neutral sphingomyelinase 3.1
CFI 2.9
tyrosine hydroxylase 2.8
PRA 2.8
PST 2.8
PAT 2.8
PHD 2.7
diacylglycerol acyltransferase 2.7
PAM 2.6
adenosine kinase 2.6
BIS 2.6
NADPH-diaphorase 2.5
adenosine deaminase 2.5
adenosine deaminase 2.5
TSA 2.2
Thy1 2.2
acetylcholinesterase 2.2
CaMKII 2.1
cholinesterase 2.0
aequorin 2.0
TOR 2.0
Mg2+-ATPase 1.9
CPT 1.8
DTA 1.8
CPT 1.7
arginase 1.6
PCP 1.6
PRE 1.6
BAL 1.5
ADH 1.4
CPT 1.3
TAT 1.3
diamine oxidase 1.2
PKG 1.2
MDP 1.1
diaphorase 1.1
NO synthase 0.9
5'-nucleotidase 0.8
renin 0.8
aldehyde dehydrogenase 0.8
aldose reductase 0.8
ACE 0.6
aldehyde dehydrogenase 0.4
aldehyde dehydrogenase 0.4
MDR 0.4
cytochrome oxidase 0.4
aldehyde dehydrogenase 0.4
hyaluronidase 0.3
alcohol dehydrogenase 0.3
MIP 0.2
DNA methyltransferase 0.2
deaminase 0.2
aldehyde dehydrogenase 0.1
CPR 0.1
glucose oxidase 0.1
diaphorase -0.0
AST -0.1
more...
Compound
DNPD 12.5
Butoctamide hydrogen succinate 12.5
Protriptyline 9.3
MPTA 8.9
Doxepin hydrochloride 8.8
3-phenylquinoline 8.6
Indeloxazine 8.4
Valerenic acid 8.4
Estazolam 8.3
MEMA 8.3
Iprindole 8.3
3-phenylquinoline 8.3
Biperiden 8.2
Dalmane 8.0
Mesoridazine 7.8
Dormicum 7.8
Zolpidem 7.7
Clonazepam 7.6
DQ1 7.4
Trazodone 7.3
Bromazepam 7.3
p-CA 7.2
Melarsoprol 7.2
Temazepam 7.1
Nortriptyline 7.1
Nitrazepam 7.1
2-amino-4-phosphonobutanoic acid 7.1
Cannabinol 7.1
Nialamide 7.0
TIB 7.0
Oxolinic acid 6.8
DPBS 6.7
THIP 6.6
Promazine 6.6
Trihexyphenidyl 6.5
Zaleplon 6.5
Sertindole 6.4
8-iso-PGF2alpha 6.4
Paroxetine 6.3
phenyl carbamate 6.2
Clomipramine 6.2
Medroxyprogesterone 6.1
Gallamine 6.0
Oleamide 5.9
Nefazodone 5.8
SHB 5.8
Maprotiline 5.8
Arecoline 5.8
Doxepin 5.8
HSM 5.8
Tolcapone 5.8
Crocetin 5.7
Ropinirole 5.7
SD 25 5.7
Betaxolol 5.6
MHPG 5.5
Piperidine 5.5
DBI 5.4
5-HTP 5.4
Chlorpheniramine 5.4
Oxotremorine 5.4
A101 5.3
5-HTP 5.3
DDM 5.3
Corticotropin 5.3
Bupropion 5.3
Chlorpheniramine 5.3
CBN 5.3
Clorgyline 5.2
Pergolide 5.2
Spiperone 5.2
Xanthohumol 5.2
EOC 5.2
Alprazolam 5.2
Tiagabine 5.2
Amitriptyline 5.1
Methylphenidate 5.1
Imipramine 5.1
Imipramine 5.1
Yohimbine 5.1
more...