Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:O75191 (H. influenzae)
 4,961 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute epiglottitis, which is almost exclusively caused by Haemophilus influenzae type b, was studied retrospectively in children 0 to 15 years old in a defined region of southwest Sweden from 1971 through 1980; 211 patients with clinically well-documented acute epiglottitis were found. The age-specific incidence was 14/100,000/year, which was higher than the incidence of H. influenzae meningitis. The median age was 4 years. Because 96% of the patients were older than 18 months, disease in those patients could theoretically have been prevented by the purified H. influenzae polysaccharide vaccine. Only a few patients had underlying diseases. In 186 patients an artificial airway was established. Even though all patients survived without sequelae, the large incidence of the disease emphasizes the importance of H. influenzae in older children.
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PMID:Incidence and prognosis of acute epiglottitis in children in a Swedish region. 633 44

Acute epiglottitis is an inflammatory, edematous disease of the epiglottis and adjacent structures, usually caused by Haemophilus influenzae type b. It is a life-threatening condition, occurring mainly in childhood. There have never been any reports of this condition in Taiwan. We report a case of 4-year-old boy who presented with characteristics of systemic illness combined with respiratory distress on arrival at the emergency room. His mouth was open and his neck was hyperextended. The diagnosis of epiglottitis was established on the basis of physical examination, lateral neck x-ray, and the finding of an enlarged, swollen, erythematous epiglottis on flexible fiberoptic laryngoscopy. Urine latex agglutination test for H. influenzae type b was positive and a blood culture grew H. influenzae type b. He was treated with cefotaxime and did not require intubation.
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PMID:Acute epiglottitis caused by Haemophilus influenzae type b: a case report. 1274 38