Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:O15079 (
syntaphilin
)
37
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Syntaxin-1 is a key component of the synaptic vesicle docking/fusion machinery that forms the SNARE complex with VAMP/synaptobrevin and
SNAP-25
. Identifying proteins that modulate SNARE complex formation is critical for understanding the molecular mechanisms underlying neurotransmitter release and its modulation. We have cloned and characterized a protein called
syntaphilin
that is selectively expressed in brain.
Syntaphilin
competes with
SNAP-25
for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1. Transient overexpression of
syntaphilin
in cultured hippocampal neurons significantly reduces neurotransmitter release. Furthermore, introduction of
syntaphilin
into presynaptic superior cervical ganglion neurons in culture inhibits synaptic transmission. These findings suggest that
syntaphilin
may function as a molecular clamp that controls free syntaxin-1 availability for the assembly of the SNARE complex, and thereby regulates synaptic vesicle exocytosis.
...
PMID:Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly. 1070 83
