Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:O14944 (EPR)
 13,097 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Alkyl radical obtained by irradiation of tetrabutylammonium decatungstate in acetonitrile in the presence of cycloalkanes (C5H10, C6H12, C7H14) are efficiently trapped by electrophilic alkenes (acrylonitrile, isopropylydenmalonitrile, isopropylydencyanoacetate) to give the corresponding alkylated aliphatic nitriles. The reaction can be carried out up to complete conversion of the alkene with reasonable (in most cases 60-65 %) yields. Addition of the radicals to the alkene is followed by electron transfer from reduced decatungstate regenerating the sensitizer (turn over number up to 60). Steady-state measurements, EPR evidence, deuteration experiments and attempted intramolecular trapping of the adduct radical support the mechanistic proposal.
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PMID:Polyoxotungstate photoinduced alkylation of electrophilic alkenes by cycloalkanes. 1469 59