Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:B6ZGS2 (
Peroxisome proliferator activated receptor gamma
)
44
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Peroxisome proliferator activated receptor gamma
(
PPARgamma
) agonist has not only antidiabetic effect but also a protective effect against various types of injury of the kidney. The protective effects of
PPARgamma
agonists are observed in diabetic nephropathy and non-diabetic renal diseases such as 5/6 ablation model of renal failure, experimental glomerulonephritis, ischemia-reperfusion injury, hypertensive nephropathy and cyclosporin-induced renal injury. The mechanism of renoprotection by
PPARgamma
agonist is multifactorial. Anti-fibrotic and anti-inflammatory effects, suppression of
renin
-angiotensin system, vascular protective effect and antiapoptotic effect were proposed.
...
PMID:Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases. 1617 87
