Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:A9QXG9 (
bcl-2
)
7,497
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This study demonstrated that the total alkaloids isolated from the traditional Chinese medicinal herb Solanum nigrum Linne (
SNL
-A) inhibited the growth of human cervical cancer HeLa cells in culture medium with much lower toxicity to human normal lymphocytes. By means of HE staining and TUNEL assay, our results further revealed that
SNL
-A induced cell death by apoptosis. An immunohistochemical assay showed down-regulation of the
bcl-2
and p53 genes and no obvious change of bax gene in the
SNL
-A treated cells. Subcutaneous injection of HeLa cells induced tumor formation in nude mice, and
SNL
-A showed a significant inhibitory effect on tumor formation. These results suggested that
SNL
-A may be a potential, natural apoptosis-inducing agent for cervical cancer.
...
PMID:Antitumor effects of total alkaloids isolated from Solanum nigrum in vitro and in vivo. 1871 90
