Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:A7KAX9 (grit)
 1,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study evaluated the effect of a grit-blasted diaphyseal surface on noncemented fixation of the Anatomic Porous Replacement II stem (APR-II, Sulzer Medica Orthopaedics, Austin, TX) for improvement of clinical results and fixation. A total of 107 consecutive total hip arthroplasties with the APR-II stem, which has proximal porous coating and a diaphyseal grit-blasted surface, were performed without cement, and 99 were studied at average 4 years. Of these hips, 37 had hydroxyapatite sprayed onto the proximal porous coating, but because there were no statistical differences for performance in any category, all stems were considered as 1 group. Clinical results were measured by the Harris hip score. Radiographic measurements of fixation, osteolysis, and bone remodeling were studied by reference to Gruen zones. Of hips, 99% had a good or excellent result by Harris hip score, with an average pain score of 42.3. Of hips, 98% had >40 points, with no patient reporting thigh pain after 3 years. There were no radiolucent lines in 94% of stems, and 100% had proximal bone ingrowth fixation. Distal cortical hypertrophy associated with tip fixation occurred in 49%, whereas proximal stress shielding was present in 43% of hips. Comparison of these clinical and radiographic results with our previous experience of bone ingrowth implants (smooth stem) suggests that bone ingrowth proximally with ongrowth in the diaphysis of the femoral stem provides better clinical and radiographic results.
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PMID:The effect of diaphyseal biologic fixation on clinical results and fixation of the APR-II stem. 1102 48

Twenty implants with sand-blasted, large-grit, acid-etched (SLA) surfaces (ITI Dental System) were followed up for a period of 12 months, during which the following clinical criteria were evaluated: (a) absence of persistent clinical symptoms (pain, strange sensations, or paresthesia) after the placement of implants; (b) absence of recurring peri-implant inflammation or suppuration; (c) absence of increasing mobility, tested with Periotest; and (d) absence of bone loss or radiolucency around the implants. After 12 months of follow-up, all the loaded implants, after 6 weeks of placement, were approved under all the aforementioned criteria. During the analysis of the increasing mobility, tested with Periotest, and grouping these implants according to the site of implantation (mandible or maxilla), it was possible to observe that the implants presented the same increasing mobility.
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PMID:Prospective clinical evaluation of dental implants with sand-blasted, large-grit, acid-etched surfaces loaded 6 weeks after surgery. 1547 Sep 95

For the improvement of surface roughness and mechanical interlocking with bone, titanium prostheses are grit-blasted with Al(2)O(3) particles during manufacturing. Dislocated Al(2)O(3) particles are a leading cause of third-body abrasive wear in the articulation of endoprosthetic implants, resulting in inflammation, pain and ultimately aseptic loosening and implant failure. In the present study, a new treatment for the removal of residual Al(2)O(3) particles from grit-blasted, cementless titanium endoprosthetic devices was investigated in a rabbit model. The cleansing process reduces residual Al(2)O(3) particles on titanium surfaces by up to 96%. The biocompatibility of the implants secondary to treatment was examined histologically, the bone-implant contact area was quantified histomorphometrically, and interface strength was evaluated with a biomechanical push-out test. Conventional grit-blasted implants served as control. In histological and SEM analysis, the Al(2)O(3)-free implant surfaces demonstrated uncompromised biocompatibility. Histomorphometrically, Al(2)O(3)-free implants exhibited a significantly increased bone-implant contact area (p=0.016) over conventional implants between both evaluation points. In push-out testing, treated Al(2)O(3)-free implants yielded less shear resistance than conventional implants at both evaluation points (p=0.018). In conclusion, the new surface treatment effectively removes Al(2)O(3) from implant surfaces. The treated implants demonstrated uncompromised biocompatibility and bone apposition in vivo. Clinically, Al(2)O(3)-free titanium prostheses could lead to less mechanical wear of the articulating surfaces and ultimately result in less aseptic loosening and longer implant life.
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PMID:The removal of Al2O3 particles from grit-blasted titanium implant surfaces: effects on biocompatibility, osseointegration and interface strength in vivo. 2008 Feb 12

This study examined factors that may enhance the relationship between resilience and time to pain threshold and tolerance during experimentally induced pain among 62 healthy adults recruited from a student population. Specifically, dispositional optimism and psychological grit were examined as moderators of the relationship between resilience and pain outcomes. Zero-order correlations revealed that resilience was positively related to grit and optimism, though grit and optimism were not significantly related to each other. Resilience, grit and optimism were all positively related to time to pain threshold and tolerance, but not pain severity. Moderation models showed that dispositional optimism enhanced the effect of resilience on both time to pain threshold and tolerance. Grit, on the other hand, was found to enhance the effect of resilience on time to pain threshold, but not time to pain tolerance. These results suggest that positive psychological factors and their interactions may be important with persevering during adverse experiences such as pain.
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PMID:The Relationship Between Psychological Resilience and Pain Threshold and Tolerance: Optimism and Grit as Moderators. 3256 16