Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:A7KAX9 (
grit
)
1,275
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To evaluate human osteoblast metabolic activity cultured in medium conditioned with commercially pure titanium after surface treatments with alumina or ceramic
grit
-blasting followed by acid etching. Commercially available, pure Grade 4 titanium disks were used and subjected to seven different surface modifications: (1) machined (MA)-used as the control group; (2) blasted with Al
2
O
3
(Al
2
O
3
); (3) blasted with sintered ceramic (
HAS
); (4) blasted with non-sintered ceramics (HA); (5) blasted with Al
2
O
3
and etched with HCl/H
2
SO
4
(Al
2
O
3
DE); (6) blasted with sintered ceramic and etched with HCl/H
2
SO
4
(
HAS
DE), and (7) blasted with non-sintered ceramic and etched with HCl/H
2
SO
4
(HA DE). A samples roughness evaluation test was carried out with an interference microscope, and energy-dispersive X-ray spectroscopy was performed to evaluate the presence of aluminum, phosphorus, and calcium deposited during the titanium surface treatment along with carbon contaminants acquired by the surface during processing. A culture medium conditioned with the respective samples was prepared in five dilutions, and its effect on human osteoblast cell viability was evaluated using the relative viability of cells. Human osteoblast metabolic activity was found to be the most intensive for the Al
2
O
3
DE sample. The lowest activity was observed for the
HAS
DE. The material's cytocompatibility depended on both the surface roughness and its chemical composition. Etching had a dual effect on cell activity, depending on the chemical composition of the titanium surface after blasting.
...
PMID:Evaluation of human osteoblast metabolic activity in modified titanium-conditioned medium. 3216 26
