Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1864663 (HCC)
 2,985 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Activity of glycolipid sulfotransferase (cerebroside sulfotransferase) in serum was elevated in 21 (33%) of 63 patients with hepatocellular carcinoma (HCC, mean +/- S.E., 349 +/- 32 pmol/ml per h, n = 63, P less than 0.001) compared to healthy subjects (172 +/- 12, n = 85). Ho significant elevation of the sulfotransferase level was observed in liver cirrhosis (219 +/- 28, n = 10) in which many of biochemical HCC markers increase concomitantly. The elevation of sulfotransferase was independent of the production of alpha-fetoprotein and of aminotransferase levels in HCC, providing complementary value for alpha-fetoprotein-negative HCC cases. However, the sulfotransferase levels (234 +/- 21, n = 32, P less than 0.01) in sera from patients with renal cell carcinoma, in whose involved tissues the enzyme was demonstrated to increase markedly, were less than in HCC.
 ...
PMID:Elevated serum level of glycolipid sulfotransferase in patients with hepatocellular carcinoma. 171 32

Lactosylsulfatide (SM3), one of the major sulfated glycolipids, has been reported to be involved in cellular adhesion. Yet, its specific function has not been well understood in tumor biology, especially in the process of metastasis. We analyzed expression levels of sulfatide on HCC cells with different metastatic potentials and found that levels were correlated with metastatic potential. Next, the cerebroside sulfotransferase (CST) (EC2.8.2.11) gene, which synthesizes SM3 as well as galactosylsulfatide (SM4), was transfected into the HCC line Hep3B. Cell surface expression of SM3 was confirmed by thin-layer chromatogram immunostaining and flow-cytometric analyses. SM3-expressing Hep3B cells showed elevated expression of integrin alphaVbeta3 and higher adhesive ability to vitronectin compared to mock cells. Furthermore, SM3 expression promoted intrahepatic metastasis in nude mice. Thus, SM3 may play an important role in the metastasis of HCC cells by causing the interaction of integrin alphaVbeta3 with vitronectin.
 ...
PMID:Lactosylsulfatide expression in hepatocellular carcinoma cells enhances cell adhesion to vitronectin and intrahepatic metastasis in nude mice. 1512 82