Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
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Enzyme
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Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Despite the success of monotherapies based on blockade of
programmed cell death 1
(
PD-1
) in human melanoma, most patients do not experience durable clinical benefit. T-cell infiltration and/or the presence of PD-L1 in tumors may be used as indicators of clinical response; However, recent studies reported that preexisting tumor-specific T cells may have limited reinvigoration capacity. Therefore, evaluating status of T cells of tumor-adjacent area and its impact on the prognosis are very important. Here, we examined 117 surgical samples from
HCC
patients for infiltration of exhausted T cell (Tex) including CD4
+
-Tex, CD8
+
-Tex and regulatory T cell (FOXP3
+
-Treg) in tumor and adjacent tissue. CD3
+
CD45RO
+
T cells were sorted from adjacent area or tumor core, then the clusters and heterogeneity of T cells were further interrogated by single-cell RNA sequencing. As a result, we suggested that abundance or location of T cell subsets is differentially correlate with long-term clinical outcome of
HCC
. In contrast with CD4
+
T or CD4
+
-Tex, the infiltration of CD8
+
T or CD8
+
-Tex cells was closely linked to overall or recurrence-free survival. FOXP3
+
-Treg is more predictive of early recurrence. Single-cell transcriptional analysis demonstrates the composition of CD4
+
-Tex, CD8
+
-Tex, and FOXP3
+
-Treg is shifted in tumor and adjacent tissue. Molecular profiles including genes coding checkpoint receptors, effector molecules are distinct between CD4
+
-Tex, CD8
+
-Tex, though some common features of CD4
+
and CD8
+
T cell exhaustion are revealed. In conclusion, we underline the heterogeneity and clinical relevance of Tex cells in
HCC
patients. A better understanding of Tex is critical for
HCC
monitoring and treatment.
...
PMID:Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma. 3242 77
