Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To better understand the response of
HCC
to EGFR inhibition, we analyzed factors connected to the resistance of
HCC
cells against gefitinib. Sensitive HCC3 cells co-expressed EGFR and ErbB3 but lacked kinase-domain mutations in EGFR. Interestingly, expression of
MVP
was restricted to resistant cell lines, whereas ABCB1 and ABCC1 showed no association with gefitinib resistance. Moreover, ectopic
MVP
expression in HCC3 cells decreased gefitinib sensitivity, increased AKT phosphorylation and reduced the expression of inflammatory pathway-associated genes, whereas silencing of
MVP
in Hep3B and HepG2 cells increased sensitivity. These findings suggest
MVP
as a novel player in resistance against EGFR inhibition.
...
PMID:The major vault protein mediates resistance to epidermal growth factor receptor inhibition in human hepatoma cells. 2226 39
