Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aberrant long noncoding RNAs (lncRNA) have been proved to be associated with the many types of malignant tumors (including hepatocellular carcinoma [
HCC
]). In this study, a lncRNAs and mRNAs microarray analysis was performed in three pairs of
HCC
patitents' tumor. We found lncRNA
LIM and SH3 protein 1
antisense (LASP1-AS) and its sense-cognate gene
LIM and SH3 protein 1
(
LASP1
) were upregulated in
HCC
and both are correlated with poorer prognosis and lower survival of
HCC
patients. Meanwhile, the expression of
LASP1
-AS correlated positively with
LASP1
expression in
HCC
tissues.
LASP1
-AS promoted the proliferation, migration, and invasion abilities of
HCC
in vitro and vivo by enhancing
LASP1
expression. Our study explored lncRNA
LASP1
-AS as an oncogene in
HCC
and promoted proliferation and metastasis capabilities of
HCC
via increasing the expression of its sense-cognate gene
LASP1
. LncRNA
LASP1
-AS might be a potential valuable prognostic biomarker and potential therapeutic target of
HCC
.
...
PMID:Increased long noncoding RNA LASP1-AS is critical for hepatocellular carcinoma tumorigenesis via upregulating LASP1. 3067 31
