Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mortalin
is highly expressed in a variety of human tumors and associated with tumor metastasis. However, the relationship among the overexpression of
Mortalin
, epithelial to mesenchymal transition (EMT) and neovascularization is largely unknown. The aim of the present study was to investigate the expression of
Mortalin
in human
HCC
cell lines, clinical
HCC
specimens and its association with angiogenesis and EMT. The results of our study showed that the expression levels of
Mortalin
in cell lines with higher metastatic potential were significantly higher compared to those with lower metastatic potential. Compared with paracarcinomatous tissues and normal liver tissues, the expression of
Mortalin
was significantly increased in
HCC
tumor tissues. The expression of
Mortalin
was correlated with invasion and metastasis, Edmondson grade and TNM stage. A significant positive correlation was found between the expression of
Mortalin
and Vimentin, and tumors with high expression of
Mortalin
had a tendency to higher MVD compared to those with low expression of
Mortalin
. Using shRNA-mediated
Mortalin
knockdown, we found that decreased expression of
Mortalin
was accompanied by a reduction of Vimentin expression. Our findings demonstrated that the overexpression of
Mortalin
is correlated with the metastatic phenotype of
HCC
cells and can promote EMT, but cannot induce angiogenesis in
HCC
. The decreased expression of
Mortalin
is accompanied by an inhibition of EMT in the
HCC
cell lines.
...
PMID:Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition. 2419 May 72
