Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Many studies reported that Oxidative stress-responsive 1(
OXSR1
) is closely related to the malignant progression of several malignancies. Nevertheless, the expression pattern and function of
OXSR1
in
HCC
remains unknown. In present research, it was observed that the expression of
OXSR1
was abnormally elevated in
HCC
. Upregulated
OXSR1
was associated with TNM stage, and grade and was confirmed as an independent prognostic factor in
HCC
patients. The downregulation of
OXSR1
expression effectively repressed the proliferation, migration and invasion of
HCC
in vivo and in vitro experiments. Western blot and qRT-PCR analysis demonstrated that mutant p53-R249S was critical for regulating the aberrant elevation of
OXSR1
in
HCC
. Chip assay indicated that p53-R249S abrogated the binding of p53 to the
OXSR1
promoter region and increased the level of POL2, H3Kac and H4Kac in the promoter region of the
OXSR1
, thus promoting the transcriptional expression of
OXSR1
. GSEA revealed that numerous cancer-related pathways were enriched in the high
OXSR1
expression group. Furthermore, the expression level of
OXSR1
was positively correlated with the infiltration levels of tumor infiltrating immune cells (TIICs) and PD-L1 expression in
HCC
by TIMER platform. In summary, our study revealed that upregulated
OXSR1
was a determinant of prognosis and immune infiltration in
HCC
. The expression of
OXSR1
was released by p53-R249S mutant, and upregulated
OXSR1
in
HCC
promoted proliferation, migration and invasion.
...
PMID:Upregulation of oxidative stress-responsive 1(OXSR1) predicts poor prognosis and promotes hepatocellular carcinoma progression. 3284 55
