Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
P21-activated kinases 6 (PAK6) associated with many fundamental cellular processes in cancer including cell-cell adhesion, migration and apoptosis. Here, we report a novel function of PAK6 in mitosis. Expression of PAK6 peaks in the M phase. Knockdown of PAK6 increases cell number in G2/M and promotes cell proliferation. PAK6 specifically colocalizes with
Eg5
in the centrosome. Depletion of PAK6 results in multipolar spindle and a simultaneous upregulation of
Eg5
. Further, the PAK6 depletion-induced multiple spindle and cell cycle progression is reversed by knockdown of
Eg5
. These data suggest that PAK6 regulates spindle formation and cell cycle by regulating
Eg5
expression. Additionally, expression of PAK6 is upregulated when
Eg5
is downregulated or inhibited. Thus, PAK6 and
Eg5
negatively inter-regulate each other. Significantly, the effect of PAK6 expression on the outcome of the
HCC
patients is controlled by
Eg5
expression. Inhibition of
Eg5
reverses PAK6 depletion-promoted cell invasion. Collectively, our data indicate that the inter-regulation between PAK6 and
Eg5
might promote the progression of
HCC
.
...
PMID:p21-activated kinase 6 controls mitosis and hepatocellular carcinoma progression by regulating Eg5. 3309 54
