Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Using
GGCX
gene-specific real-time PCR, exon 2 deletion splice variant of vitamin K-dependent
gamma-glutamyl carboxylase
(
GGCX
) mRNA was identified in
HCC
cell lines. Expressions of wild type and exon 2 deletion variant of
GGCX
were analyzed with relevance to DCP production in
HCC
cell lines. Hep3B, HepG2, HuH1, HuH7, and PLC/PRF/5 produced DCP, while SK-Hep-1, HLE, HLF, and JHH1 produced no detectable level of DCP. DCP-producing cells expressed exon 2 deletion variant of
GGCX
mRNA and protein, while DCP-negative cells expressed no detectable level of exon 2 deletion variant of
GGCX
. These results suggest that exon 2 deletion splice variant of
GGCX
causes dysfunction of
GGCX
enzyme activity resulting in DCP production in
HCC
cell lines.
...
PMID:Exon 2 deletion splice variant of gamma-glutamyl carboxylase causes des-gamma-carboxy prothrombin production in hepatocellular carcinoma cell lines. 1938 45
