Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Most studies about serpin peptidase inhibitor, clade A member 3 (SERPINA3) has been limited to its inhibitory functions and mechanisms. Herein, we report a novel role of SERPINA3 in transcriptional regulation of
HCC
progression-related genes. Among 19 selected genes through
HCC
cell isolation system based on telomere length, microarray analyses, and cell-based studies, SERPINA3 was the strongest determinant of increases in telomere length,
HCC
cell proliferation, survival, migration, and invasion. We also found that SERPINA3 strongly interacted with
heterogeneous nuclear ribonucleoprotein K
(HNRNP-K) under H
2
O
2
exposure, and the oxidation-elicited SERPINA3-HNRNP-K complex enhanced the promoter activities and transcript levels of a telomere-relating gene (POT1) and
HCC
-promoting genes (UHRF1 and HIST2H2BE). Intriguingly, the inhibition of SERPINA3 oxidation rendered the transcriptional activity of the SERPINA3-HNRNP-K complex suppressed. Moreover, the co-immunoprecipitated HNRNP-K with SERPINA3 quantitatively correlated with not only the level of SERPINA3 oxidation but also the level of POT1, UHRF1, and HIST2H2BE transcripts and telomere length in
HCC
tissues. Therefore, the upregulated transcriptional activity of HNRNP-K mediated by SERPINA3 promotes
HCC
cell survival and proliferation and could be an indicator of poor prognosis for
HCC
patients.
...
PMID:SERPINA3 is a key modulator of HNRNP-K transcriptional activity against oxidative stress in HCC. 3112 93
